| Role of lymphangiogenic factors in tumor metastasis. | |
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MedLine Citation:
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PMID: 14984763 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nearly four centuries after the discovery of lymphatic vessels, the molecular mechanisms underlying their development are beginning to be elucidated. Vascular endothelial growth factor C (VEGF-C) and VEGF-D, via signaling through VEGFR-3, appear to be essential for lymphatic vessel growth. Observations from clinicopathological studies have suggested that lymphatic vessels serve as the primary route for the metastatic spread of tumor cells to regional lymph nodes. Recent studies in animal models have provided convincing evidence that tumor lymphangiogenesis facilitates lymphatic metastasis. However, it is not clear how tumor-associated lymphangiogenesis is regulated, and little is known about how tumor cells escape from the primary tumor and gain entry into the lymphatics. This review examines some of these issues and provides a brief summary of the recent developments in this field of research. |
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Authors:
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Yulong He; Terhi Karpanen; Kari Alitalo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1654 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-26 Completed Date: 2004-06-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3-12 Citation Subset: IM |
Affiliation:
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Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, POB 63 (Haartmaninkatu 8), 00014 Helsinki, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Lymphatic Metastasis Lymphatic Vessels / physiology* Necrosis Neoplasm Metastasis / immunology, physiopathology* Vascular Endothelial Growth Factor C / physiology* Vascular Endothelial Growth Factor D / physiology* Vascular Endothelial Growth Factor Receptor-3 / antagonists & inhibitors, physiology |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor C; 0/Vascular Endothelial Growth Factor D; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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