Document Detail

Role of lung surfactant in cerebral decompression sickness.
MedLine Citation:
PMID:  6687549     Owner:  NLM     Status:  MEDLINE    
Five dogs have been embolized by air infusion into the venous system, then sacrificed and the pulmonary vasculature isolated by ligatures while ventilation was maintained for a further hour. In a sixth animal, the embolization was omitted. The lungs were back-perfused with plasma from the same dog and successive aliquots of the back-flushings analysed by thin-layer chromatography (TLC), each spot being removed for phosphorus determination. The results showed that the major lipid component was the phosphatidyl cholines, while lysophosphatidyl cholines, phosphatidyl ethanolamines, and sphingomyelins were also identified in significant quantities. A phosphorus balance for the lungs showed a significant migration of phospholipids from the tissue into pulmonary blood, phosphatidyl cholines increasing by a factor of 10.6. This migration of surfactant is discussed as an important factor in determining whether trapped pulmonary air emboli are released into the arterial system when their surface area is reduced by pressurization, suggesting that recompression should not be too rapid.
B D Butler; B A Hills
Related Documents :
16338299 - Liver position in fetal congenital diaphragmatic hernia retains a prognostic value in t...
1474089 - Different ventilation strategies alter surfactant responses in preterm rabbits.
8979049 - Circulatory changes after surfactant bolus instillation in lung-lavaged adult rabbits.
9138589 - Micropipette aspiration of human erythrocytes induces echinocytes via membrane phosphol...
12955179 - Synthetic and natural surfactant differentially modulate inflammation after meconium as...
8331699 - Pulmonary biophysical effects of triiodothyronine augmentation during sepsis-induced hy...
12198339 - Assessment of repeatability and correlates of arterial compliance.
8227469 - Assessment of blood pressure during treatment with naproxen or ibuprofen in hypertensiv...
2565369 - Effects of release rates on the range of attraction of carbon dioxide to some southwest...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  54     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-15     Citation Subset:  IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromatography, Thin Layer
Decompression Sickness / etiology*
Embolism, Air / complications
Intracranial Embolism and Thrombosis / etiology*
Lung / physiology*
Pulmonary Embolism / complications
Pulmonary Surfactants / physiology*
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A computer data bank system for otolaryngologic and audiologic data.
Next Document:  Pharmacokinetics of atracurium besylate in healthy patients (after a single i.v. bolus dose).