Document Detail


Role of lung surfactant in cerebral decompression sickness.
MedLine Citation:
PMID:  6687549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five dogs have been embolized by air infusion into the venous system, then sacrificed and the pulmonary vasculature isolated by ligatures while ventilation was maintained for a further hour. In a sixth animal, the embolization was omitted. The lungs were back-perfused with plasma from the same dog and successive aliquots of the back-flushings analysed by thin-layer chromatography (TLC), each spot being removed for phosphorus determination. The results showed that the major lipid component was the phosphatidyl cholines, while lysophosphatidyl cholines, phosphatidyl ethanolamines, and sphingomyelins were also identified in significant quantities. A phosphorus balance for the lungs showed a significant migration of phospholipids from the tissue into pulmonary blood, phosphatidyl cholines increasing by a factor of 10.6. This migration of surfactant is discussed as an important factor in determining whether trapped pulmonary air emboli are released into the arterial system when their surface area is reduced by pressurization, suggesting that recompression should not be too rapid.
Authors:
B D Butler; B A Hills
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  54     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-15     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Thin Layer
Decompression Sickness / etiology*
Dogs
Embolism, Air / complications
Intracranial Embolism and Thrombosis / etiology*
Lung / physiology*
Pulmonary Embolism / complications
Pulmonary Surfactants / physiology*
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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