Document Detail


Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young athletes.
MedLine Citation:
PMID:  12070194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined whether lung inflammatory mediators are increased during exercise and whether pharmacological blockade can prevent exercise-induced arterial hypoxemia (EIAH) in young athletes. Seventeen healthy athletes (9 men, 8 women; age 23 +/- 3 yr) with varying degrees of EIAH completed maximal incremental treadmill exercise tests after administration of fexofenadine, zileuton, and nedocromil sodium or placebo in a randomized double-blind crossover study. Lung function, arterial blood gases, and inflammatory metabolites in plasma, urine, and induced sputum were assessed. Drug administration did not improve EIAH or gas exchange during exercise. At maximal exercise, oxygen saturation fell to 91.4 +/- 2.6% (drug trial) and 91.9 +/- 2.1% (placebo trial) and alveolar-arterial oxygen difference widened to 28.1 +/- 6.3 Torr (drug trial) and 29.3 +/- 5.7 Torr (placebo trial). Oxygen consumption, ventilation, and other exercise variables were similarly unaffected by drug treatment. Although plasma histamine increased with exercise, values did not differ between trials, and urinary leukotriene E(4) and 11beta-prostaglandin F(2alpha) levels were unchanged after exercise. Postexercise sputum revealed no significant changes in markers of inflammation. These results demonstrate that EIAH in young athletes is not attenuated with acute administration of drugs targeting histamine and bioactive lipids. We conclude that airway inflammation is of insufficient magnitude to cause impairments in gas exchange and does not appear to be linked to EIAH in healthy young athletes.
Authors:
Thomas J Wetter; Zhuzai Xiang; David A Sonetti; Hans C Haverkamp; Anthony J Rice; Adnan A Abbasi; Keith C Meyer; Jerome A Dempsey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  93     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-18     Completed Date:  2002-12-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-26     Citation Subset:  IM    
Affiliation:
John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, Clinical Sciences Center, University of Wisconsin, Madison 53705, USA. tjwetter@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / blood*
Cell Count
Exercise / physiology*
Female
Histamine H1 Antagonists / pharmacology
Humans
Hydroxyurea / analogs & derivatives*,  pharmacology
Inflammation Mediators / antagonists & inhibitors,  metabolism*
Leukotriene Antagonists / pharmacology
Leukotriene E4 / blood
Lung / physiology*
Male
Oxygen Consumption / physiology
Pulmonary Gas Exchange / physiology
Respiratory Function Tests
Sports / physiology*
Sputum / chemistry,  cytology
Terfenadine / analogs & derivatives*,  pharmacology
Grant Support
ID/Acronym/Agency:
HL-15469/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Histamine H1 Antagonists; 0/Inflammation Mediators; 0/Leukotriene Antagonists; 127-07-1/Hydroxyurea; 132880-11-6/zileuton; 138452-21-8/fexofenadine; 50679-08-8/Terfenadine; 75715-89-8/Leukotriene E4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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