Document Detail


Role of the lung in accumulation and metabolism of xenobiotic compounds--implications for chemically induced toxicity.
MedLine Citation:
PMID:  7612175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mammalian lung is exposed to and affected by many airborne and bloodborne foreign compounds. This review summarizes the role of lung in accumulation and metabolism of xenobiotics, some of which are spontaneously reactive or are metabolically activated to toxic intermediates. The specific architectural arrangement of mammalian lung favors that so-called pneumophilic drugs are filtered out of the blood and are retained within the tissue as shown in particular for amphetamine, chlorphentermine, amiodarone, imipramine, chlorpromazine, propranolol, local anaesthetics, and some miscellaneous therapeutics. There is strong evidence that intrapulmonary distribution activity and regulation of drug-metabolizing enzymes in lung is distinct from liver. This review focuses on the metabolic rate of selected compounds in lung such as 5-fluoro-2'-deoxyuridine, local anesthetics, nicotine, benzo(alpha)pyrene, ipomeanol, 4-methylnitrosamino-1-(3-pyridyl)-1-butanone. It is widely accepted that the formation of radical species is a key event in the pneumotoxic mechanisms induced by bleomycin, paraquat, 3-methylindole, butylhydroxytoluene, or nitrofurantoin. Finally, methodological approaches to assess the capacity of lung to eliminate foreign compounds as well as biochemical features of the pulmonary tissue are evaluated briefly.
Authors:
H Foth
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in toxicology     Volume:  25     ISSN:  1040-8444     ISO Abbreviation:  Crit. Rev. Toxicol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-18     Completed Date:  1995-08-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8914275     Medline TA:  Crit Rev Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-205     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, University of Göttingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Lung / drug effects,  metabolism*
Lung Diseases / chemically induced
Xenobiotics / metabolism*,  poisoning*
Chemical
Reg. No./Substance:
0/Xenobiotics

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