Document Detail

Role of long-term potentiation of sympathetic ganglia (gLTP) in hypertension.
MedLine Citation:
PMID:  17653963     Owner:  NLM     Status:  MEDLINE    
Ganglionic long-term potentiation (gLTP) is an activity-dependent sustained increase in the synaptic efficacy of the nicotinic pathway that has been demonstrated in autonomic ganglia. Sustained enhancement in ganglionic transmission as in chronic mental stress may affect the activity of autonomic functions, including blood pressure and heart rate. An increase in sympathetic activity associated with psychosocial stress and stress-prone conditions such as obesity and aging could result in in vivo expression of gLTP leading to hypertension of a neural origin. Recent reports indicated that the prevention of the expression of gLTP in animal models of hypertension prevented or reduced high blood pressure. Although stress-induced hypertension normalizes within a few days of stress relief, prolonged mild-moderate hypertension may contribute to atherosclerotic cardiovascular diseases. The relation between hypertension and enhanced ganglionic transmission as a result of in vivo expression of gLTP is discussed in this review.
Karim Alkadhi; Karem Alzoubi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  29     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-86     Citation Subset:  IM    
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204-5515, USA.
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MeSH Terms
Aging / physiology
Blood Pressure / physiology
Disease Models, Animal
Electric Stimulation
Ganglia, Sympathetic / physiopathology*
Hypertension / etiology,  physiopathology*
Long-Term Potentiation / physiology*
Obesity / physiopathology
Ouabain / toxicity
Rats, Inbred SHR
Rats, Zucker
Receptors, Serotonin / physiology
Stress, Psychological / complications,  physiopathology
Reg. No./Substance:
0/Receptors, Serotonin; 630-60-4/Ouabain

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