Document Detail

Role of locus coeruleus heme oxygenase-carbon monoxide-cGMP pathway during hypothermic response to restraint.
MedLine Citation:
PMID:  18355628     Owner:  NLM     Status:  MEDLINE    
Central heme oxigenase-carbon monoxide (HO-CO) pathway has been shown to play a pyretic role in the thermoregulatory response to restraint. However, the specific site in the central nervous system where CO may act modulating this response remains unclear. LC is rich not only in sGC but also in heme oxygenase (HO; the enzyme that catalyses the metabolism of heme to CO, along with biliverdin and free iron). Therefore, the possible role of the HO-CO-cGMP pathway in the restraint-induced-hypothermia by LC neurons was investigated. Body temperature dropped about 0.7 degrees C during restraint. ZnDPBG (a HO inhibitor; 5 nmol, intra-LC) prevented the hypothermic response during restraint. Conversely, induction of the HO pathway in the LC with heme-lysinate (7.6 nmol, intra-LC) intensified the hypothermic response to restraint, and this effect was prevented by pretreatment with ODQ (a sGC inhibitor; given intracerebroventricularly, 1.3 nmol). Taken together, these data suggest that CO in the LC produced by the HO pathway and acting via cGMP is implicated in thermal responses to restraint.
Maria Ida Bonini Ravanelli; Luiz G S Branco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-02
Journal Detail:
Title:  Brain research bulletin     Volume:  75     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  526-32     Citation Subset:  IM    
Department of Physiology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
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MeSH Terms
Behavior, Animal
Body Temperature / drug effects
Carbon Monoxide / metabolism*
Cyclic GMP / metabolism*
Deuteroporphyrins / pharmacology
Enzyme Inhibitors / pharmacology
Heme / analogs & derivatives,  pharmacology
Heme Oxygenase (Decyclizing) / metabolism*
Hypothermia / metabolism*,  pathology
Locus Coeruleus / enzymology*
Lysine / analogs & derivatives,  pharmacology
Rats, Wistar
Restraint, Physical / methods
Reg. No./Substance:
0/Deuteroporphyrins; 0/Enzyme Inhibitors; 0/heme lysinate; 119700-81-1/zinc deuteroporphyrin IX 2,4-bis(glycol); 14875-96-8/Heme; 56-87-1/Lysine; 630-08-0/Carbon Monoxide; 7665-99-8/Cyclic GMP; EC Oxygenase (Decyclizing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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