Document Detail

Role of the locus coeruleus on blood pressure response and atrial natriuretic peptide secretion following extracellular volume expansion.
MedLine Citation:
PMID:  10566978     Owner:  NLM     Status:  MEDLINE    
Extracellular volume expansion (EVE) was performed in intact rats and 24 h after locus coeruleus (LC) lesions or sham-operation. Blood pressure was registered 5 min before and after EVE. At the end of the experiment the animals were decapitated and blood was collected from the trunk for quantification of plasma atrial natriuretic peptide (ANP). All experimental groups showed similar basal blood pressure. Volume expansion caused a slight decrease in blood pressure and an increase in ANP secretion in all groups, but these changes were significantly enhanced in animals bearing a lesion in the anterior region of the LC. There was no pronounced c-fos expression in any region of the LC 2 h after EVE in intact animals. In conclusion, the data support the idea that the LC does not participate in blood pressure control in resting conditions. However, the anterior region of the LC seems to play a role when adjustments of blood pressure and excretion of water and sodium are necessary during changes in blood volume. The results on c-fos expression are in accordance with the idea that this nucleus may be part of an inhibitory pathway which modulates the circuits of control for depressor reflex response and ANP secretion after extracellular volume expansion.
J A Anselmo-Franci; M J Rocha; V L Peres-Polon; E R Moreira; J Antunes-Rodrigues; C Rodrigues Franci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research bulletin     Volume:  50     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-02     Completed Date:  1999-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Departamento de Morfologia, Estomatologia e Fisiologia, da Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Brasil.
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MeSH Terms
Atrial Natriuretic Factor / blood*,  secretion
Blood Pressure / physiology*
Blood Volume / physiology
Extracellular Space / physiology
Locus Coeruleus / physiology*
Proto-Oncogene Proteins c-fos / analysis,  biosynthesis
Rats, Wistar
Reference Values
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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