| Role of local pancreatic blood flow in development of hemorrhagic pancreatitis induced by stress in rats. | |
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MedLine Citation:
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PMID: 7689731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our previous data showed that the pancreatitis induced in rats by cerulein develops into hemorrhagic pancreatitis following water-immersion stress. The present study examined the effects of water-immersion stress and high doses of cerulein (intraperitoneal injection) on pancreatic blood flow. Five hours of water-immersion stress reduced the local pancreatic blood flow to approximately 30% of the initial value (253.75 +/- 12.58 ml/min/100 g) without causing any histological alterations. Blood flow was decreased as early as 1 h after the immersion and reached the lowest value (30% of initial value) 3 h after the immersion. The administration of 40 micrograms/kg body wt cerulein as two intraperitoneal injections reduced the pancreatic blood flow by 40% 5 h after the first cerulein injection. The injections of cerulein combined with water-immersion stress did not reduce the pancreatic blood flow more than did water-immersion stress alone. The systemic blood pressure was unaffected during 5 h of water immersion after the cerulein injections. These findings suggest that in rats the stress-induced decrease of local pancreatic blood flow may not produce pancreatitis, but may aggravate an existing acute pancreatitis. |
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Authors:
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M Furukawa; T Kimura; T Sumii; H Yamaguchi; H Nawata |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 8 ISSN: 0885-3177 ISO Abbreviation: Pancreas Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-09-27 Completed Date: 1993-09-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 499-505 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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blood Animals Capillaries / pathology Dopamine / pharmacology Endothelium, Vascular / pathology Hemorrhage / etiology, pathology, physiopathology* Male Organ Size / physiology Pancreas / blood supply*, pathology Pancreatitis / etiology, pathology, physiopathology* Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects, physiology Stress, Physiological / physiopathology* Thrombosis / etiology, pathology Vasopressins / pharmacology |
| Chemical | |
Reg. No./Substance:
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11000-17-2/Vasopressins; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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