| Role of liver transplantation in cancer therapy. | |
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MedLine Citation:
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PMID: 2996449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-four patients underwent total hepatectomy and liver replacement in the presence of a primary liver malignancy. In 13 recipients in whom the hepatic tumors were incidental to some other endstage liver disease, recurrence was not seen and 12 of the 13 patients are alive after 4 months to 15 1/2 years. In contrast, tumors recurred in 3 of every 4 patients who received liver replacement primarily because of hepatic malignancies that could not be resected by conventional techniques of subtotal hepatectomy and who lived for at least 2 months after transplantation. The most encouraging results were in patients with the fibrolamellar hepatocellular carcinomas that grow slowly and metastasize late, but even with this lesion, the recurrence rate was 57%. In future trials, additional effective anticancer therapy will be needed to improve the results of liver transplantation for primary liver malignancy, but what an improved strategy should be has not yet been defined. |
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Authors:
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S Iwatsuki; R D Gordon; B W Shaw; T E Starzl |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of surgery Volume: 202 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-11-15 Completed Date: 1985-11-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 401-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carcinoma, Hepatocellular / mortality, surgery, therapy* Child Child, Preschool Female Hepatectomy Humans Liver Diseases / surgery, therapy Liver Neoplasms / mortality, surgery, therapy* Liver Transplantation* Male Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local |
| Grant Support | |
ID/Acronym/Agency:
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AM-29961/AM/NIADDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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