Document Detail

Role of lipids in the immune response. II. An enhancer of antibody production (APS) that is a lipid closely associated with lymphocyte mitogenic factor (LMF).
MedLine Citation:
PMID:  381518     Owner:  NLM     Status:  MEDLINE    
Lymphocyte mitogenic factor (LMF) is a lymphokine produced by dividing T cells. An activity coeluting with LMF from a Sephadex resin is extractable from LMF with chloroform-methanol. It enhances but does not initiate antibody formation measured by generation of plaque-forming cells (PFC). It does not cause proliferation of B cells. This activity elutes from a silicic acid column and produces a pattern on thin layer chromatography that suggests that the compound(s) responsible for the activity is a polar lipid.
R L Wolf; E Merler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  123     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1175-80     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody Formation*
Cell Extracts / immunology
Chromatography, Thin Layer
Galactosamine / metabolism
Galactose / metabolism
Glucosamine / metabolism
Hemolytic Plaque Technique
Lipids / immunology*
Lymphocyte Activation
Lymphokines / pharmacology*
Silicic Acid / pharmacology
Reg. No./Substance:
0/Cell Extracts; 0/Lipids; 0/Lymphokines; 1343-98-2/Silicic Acid; 26566-61-0/Galactose; 3416-24-8/Glucosamine; 7535-00-4/Galactosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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