| Role of lifestyle factors on plasma homocysteine levels in Parkison's disease patients treated with levodopa. | |
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MedLine Citation:
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PMID: 16910165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many papers documented that Parkinson's disease (PD) patients treated with levodopa (L-dopa) shows elevated plasma homocysteine (Hcy) levels. Several lifestyle factors are able to influence plasma Hcy levels. We review the evidence that L-dopa therapy is related with an increase in plasma Hcy levels and that several behaviours could be able to cause changes in plasma Hcy concentrations. Therefore, there are reasons to suggest that a healthy lifestyle lowering Hcy may prevent this potential iatrogenic complication during L-dopa therapy. Moreover, at present, no controlled prospective studies have evaluated this phenomenon. |
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Authors:
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Antonio Siniscalchi; Luca Gallelli; Nicola B Mercuri; Guido Ferreri Ibbadu; Giovambattista De Sarro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nutritional neuroscience Volume: 9 ISSN: 1028-415X ISO Abbreviation: Nutr Neurosci Publication Date: 2006 Feb-Apr |
Date Detail:
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Created Date: 2006-08-16 Completed Date: 2006-09-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 11-6 Citation Subset: IM |
Affiliation:
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Neurology Division, Department of Neuroscience, "Annunziata" Hospital, Cosenza, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiparkinson Agents
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adverse effects*,
therapeutic use Folic Acid / administration & dosage Homocysteine / blood*, genetics, metabolism Levodopa / adverse effects*, therapeutic use Life Style* Parkinson Disease / blood*, drug therapy* Polymorphism, Genetic Riboflavin / administration & dosage Vitamin B 6 / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Levodopa; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 8059-24-3/Vitamin B 6; 83-88-5/Riboflavin |
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