Document Detail

Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media.
MedLine Citation:
PMID:  8973284     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the role of polymorphonuclear leukocytes (PMNs) in acute otitis media (AOM), levels of leukotriene B4 (LTB4), a potent inflammatory product of PMNs, and interleukin-8 (IL-8), a PMN chemotactic cytokine, were measured in 271 middle ear fluid (MEF) samples from 106 children with AOM. Forty-two percent of the patients had evidence of respiratory viral infection. At the time of diagnosis, levels of both LTB4 and IL-8 were higher in the MEFs from patients with AOM associated with bacterial or bacterial and viral infection than those MEFs containing no pathogen (p < .05). Antibiotic treatment was not associated with a significant change in levels of LTB4 or IL-8 in the MEFs obtained 2 to 5 days into treatment, compared to those obtained at diagnosis. Bacteriologic failure after 2 to 5 days of treatment was associated with high LTB4 levels in the initial MEFs (p = .05). Recurrence of AOM within 1 month was associated with high IL-8 levels in the initial MEF (p = .04). Our findings suggest that LTB4 and IL-8 are produced during acute infection of the middle ear, and these PMN-related inflammatory substances may play an important role in delaying recovery or in recurrence of AOM. Effective treatment of AOM may require eradication of bacteria by antibiotics, as well as pharmacologic agents that modulate PMN functions.
T Chonmaitree; J A Patel; T Sim; R Garofalo; T Uchida; T Sim; V M Howie; M J Owen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  105     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  968-74     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Texas Medical Branch at Galveston 77555-0371, USA.
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MeSH Terms
Bacterial Infections / complications
Enzyme-Linked Immunosorbent Assay
Interleukin-8 / physiology*
Leukotriene B4 / physiology*
Neutrophils / physiology*
Otitis Media / immunology,  microbiology*,  virology
Respiratory Tract Infections / complications,  microbiology
Virus Diseases / complications
Grant Support
Reg. No./Substance:
0/Interleukin-8; 71160-24-2/Leukotriene B4

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