Document Detail

Role of leptin in the stomach and the pancreas.
MedLine Citation:
PMID:  11595459     Owner:  NLM     Status:  MEDLINE    
Leptin, a 16 kDa protein encoded by the ob gene, is known mainly for its role in the regulation of food intake, body composition and energy expenditure through a central feedback mechanism. Initially leptin was considered as an ob gene product of adipocytes but recently the presence of leptin and its receptors have been revealed in other organs including gastric mucosa and the pancreas and found to be released from these organs by cholecystokinin (CCK), gastrin and ordinary feeding. Furthermore, leptin was found to mimic the action of CCK on gastric and pancreatic integrity, while reducing the food intake and to affect gastric and pancreatic secretion. This report emphasizes the role of leptin originating from the gastrointestinal tract acting synergistically with CCK at the hypothalamus level on the mechanism of food intake and locally on the protection of gastric mucosa and the pancreas against noxious agents and to maintain tissue integrity.
P C Konturek; S J Konturek; T Brzozowski; J Jaworek; E G Hahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology, Paris     Volume:  95     ISSN:  0928-4257     ISO Abbreviation:  J. Physiol. Paris     Publication Date:    2001 Jan-Dec
Date Detail:
Created Date:  2001-10-11     Completed Date:  2002-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9309351     Medline TA:  J Physiol Paris     Country:  France    
Other Details:
Languages:  eng     Pagination:  345-54     Citation Subset:  IM    
Department of Medicine, University of Erlangen-Nuremberg, Erlangen, Germany.
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MeSH Terms
Acute Disease
Aspirin / pharmacology
Cholecystokinin / pharmacology
Ethanol / pharmacology
Gastric Mucosa / drug effects,  pathology,  physiology
Gene Expression
Leptin / genetics,  pharmacology,  physiology*
Pancreas / physiology*
Pancreatitis / pathology
Rats, Wistar
Restraint, Physical
Sincalide / pharmacology
Stomach / physiology*
Reg. No./Substance:
0/Leptin; 25126-32-3/Sincalide; 50-78-2/Aspirin; 64-17-5/Ethanol; 9011-97-6/Cholecystokinin

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