Document Detail


Role of leptin in reproduction.
MedLine Citation:
PMID:  15166788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This article focuses on recently gained knowledge concerning the different emerging aspects of the role of leptin in reproduction, through both its central hypothalamus-mediated and peripheral actions. RECENT FINDINGS: As delineated in murine models, STAT3-independent signals triggered by the leptin receptor are clearly important in fertility, and candidate pathways such as those via phosphatidylinositol-3 kinase and extracellular signal-related kinase are implicated in leptin-regulated cascades. Another aspect whose importance has recently been revealed is that of the bioavailability of leptin in general, and the fate and action of carrier-bound versus free leptin at central and peripheral sites in particular. SUMMARY: Besides the well-established role of leptin in the control of appetite and energy expenditure in humans and animals, evidence for a major involvement of the hormone in the function of the reproductive system is rapidly accumulating through physiological and molecular genetic approaches. Powerful animal models that facilitate the dissection of increasingly complex pathways, together with detailed studies in man, will soon delineate in detail the diverse roles of leptin in biological regulation. The development of therapeutic agents primarily directed against obesity must therefore take into consideration the consequences of treatment not only on the amelioration of leptin resistance, but also on the bioactivity of leptin in the context of growth, glucose homeostasis, and last but not least, fertility.
Authors:
Tarek M Bajari; Johannes Nimpf; Wolfgang J Schneider
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  15     ISSN:  0957-9672     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2005-10-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  England    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
Affiliation:
Max F. Perutz Laboratories, Institute of Medical Biochemistry, Department of Molecular Genetics, Medical University of Vienna, Dr Bohr Gasse 9/2, A-1030 Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
1-Phosphatidylinositol 3-Kinase / metabolism
Animals
DNA-Binding Proteins / physiology
Fertility / physiology
Gonads / physiology
Humans
Hypothalamus / physiology
Lactation / physiology
Leptin / physiology*
Pituitary Gland / physiology
Receptors, Cell Surface / metabolism
Receptors, Leptin
Reproduction / physiology*
STAT3 Transcription Factor
Trans-Activators / physiology
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/STAT3 Transcription Factor; 0/STAT3 protein, human; 0/Trans-Activators; 0/leptin receptor, human; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase

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