Document Detail


Role of leptin in pregnancy: Consequences of maternal obesity.
MedLine Citation:
PMID:  23332215     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Maternal obesity is associated with increased risks of pregnancy complications. Excessive fat mass, common to obese women, has the potential to influence production and secretion of adipose tissue derived proteins called adipokines. The adipokine leptin is involved in the regulation of multiple aspects of maternal metabolic homeostasis. In addition, leptin has been shown to be important for placentation and maternal-fetal exchanges processes regulating growth and development. In later stages of a healthy pregnancy, central leptin resistance occurs to allow increased nutrient availability for the fetus. Disruption of the signaling capacity of leptin associated with obesity is emerging as a potential risk factor leading to pregnancy complications as a result of aberrant fuel partitioning in utero. In this review we discuss the influence of obesity on the roles of leptin and leptin resistance at the central and placental level.
Authors:
D R Tessier; Z M Ferraro; A Gruslin
Related Documents :
11022925 - Neonatal screening for cystic fibrosis in brittany, france: assessment of 10 years' exp...
19915395 - Screening for fetal aneuploidy and neural tube defects.
17003555 - Cftr deltaf508 mutation detection from dried blood samples in the first trimester of pr...
20638585 - First- and second-trimester screening for preeclampsia and intrauterine growth restrict...
893565 - Glycosyltrasferase activity in developing sea-urchin embryos.
18192655 - Effects of different intervention strategies on the incidence of papillomatous digital ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; Chronic Disease Program, Dept Cellular Molecular Medicine, Ottawa Hospital Research Institute, Ottawa, ON K1Y4E9, Canada. Electronic address: dtess036@uottawa.ca.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Laboratory-Based Cryogenic Soft X-Ray Tomography with Correlative Cryo-Light and Electron Microscopy...
Next Document:  Innate and adaptive immune responses to the major Parietaria allergen Par j 1 in healthy subjects.