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Role of leptin in the pancreatic beta-cell: effects and signalling pathways.
MedLine Citation:
PMID:  22448029     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Leptin plays an important role in the control of food intake, energy expenditure, metabolism and body weight. This hormone has also a key function in the regulation of glucose homeostasis. Although leptin acts through central and peripheral mechanisms to modulate glucose metabolism, the pancreatic beta-cell of the endocrine pancreas is a critical target of leptin actions. Leptin receptors are present in the beta-cell, and their activation directly inhibits insulin secretion from these endocrine cells. The effects of leptin on insulin take also place in the long term, since this hormone inhibits insulin gene expression as well. Additionally, beta-cell mass can be affected by leptin through changes in proliferation, apoptosis or cell size. All these different functions in the beta-cell are triggered by leptin as a result of the large diversity of signalling pathways that this hormone is able to activate in the endocrine pancreas. Therefore, leptin can participate in glucose homeostasis owing to different levels of modulation of the pancreatic beta-cell population. Furthermore, it has been proposed that alterations in this level of regulation could contribute to the impairment of beta-cell function in obesity states. In the present review, we will discuss all these issues with special emphasis on the effects and pathways of leptin signalling in the pancreatic beta-cell.
Authors:
Laura Marroqui; Alejandro González; Patricia Neco; Ernesto Caballero-Garrido; Elaine Vieira; Cristina Ripoll; Angel Nadal; Ivan Quesada
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Journal of molecular endocrinology     Volume:  -     ISSN:  1479-6813     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902617     Medline TA:  J Mol Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
L Marroqui, Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, 03202, Spain.
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