Document Detail


Role of kinin B1 and B2 receptors and mast cells in post intestinal infection-induced hypersensitivity to distension.
MedLine Citation:
PMID:  10050255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Distension of the rat intestine causes a capsaicin-sensitive, pressure-dependent depressor response which is indicative of nociception. A hypersensitivity of jejunal distension which possibly involves tachykinin NK2 receptors and is restricted to areas with mast cell hyperplagia is observed in rats infected 30 days previously with Nippostrongylus brasiliensis. This study aimed to further investigate the role of mast cells, tachykinins and kinins in this intestinal hypersensitivity. The activity of a mast cell stabilizer (doxantrazole), kinin antagonists (des-Arg 10-[Leu9]-kallidin, B1, HOE 140, B2) and tachykinin antagonists (CP 99, 994, NK1, SR 142801, NK3) were tested against the distension-induced depressor responses in control and post-infected rats. The 30-day post-infection-induced hypersensitivity was significantly reduced by the mast cell stabilizer doxantrazole. The hypersensitivity had resolved in 90-day post-infected rats when mast cells levels had normalized. Des-Arg 10-[Leu9]-kallidin and HOE 140 did not inhibit the depressor responses in controls but produced a significant inhibition in 30-day post-infected rats. CP 99,994 inhibited the depressor responses in post-infected rats with an equal potency to that in control rats. SR 142801 was inactive in both groups. In conclusion, mast cells and kinin-mediated nociception appear to be involved in post-infection intestinal hypersensitivity whereas tachykinin NK1 and NK3 receptors do not.
Authors:
P G McLean; C Picard; R Garcia-Villar; R Ducos de Lahitte; J Moré; J Fioramonti; L Buéno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  10     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-05-04     Completed Date:  1999-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  499-508     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Institut National de la Recherche Agronomique, Toulouse, France. p.mclean@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Balloon Dilatation
Intestinal Diseases / parasitology*,  physiopathology*
Jejunum / physiopathology*
Male
Mast Cells / physiology*
Nippostrongylus
Rats
Rats, Wistar
Receptor, Bradykinin B1
Receptor, Bradykinin B2
Receptors, Bradykinin / physiology*
Receptors, Tachykinin / physiology
Strongylida Infections / complications,  physiopathology*
Time Factors
Chemical
Reg. No./Substance:
0/Receptor, Bradykinin B1; 0/Receptor, Bradykinin B2; 0/Receptors, Bradykinin; 0/Receptors, Tachykinin

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