| Role of iron deficiency anemia in the propagation of beta thalssemia gene. | |
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MedLine Citation:
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PMID: 21461303 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The diagnostic criterion for beta thalassemia trait (BTT) is elevated Hb-A(2) levels. Iron deficiency anemia (IDA) reduces the synthesis of Hb-A(2), resulting in reduced Hb-A(2) levels, so patients with co-pathological conditions BTT with IDA, may have a normal level of Hb-A(2). Many socio-economic factors like unawareness, poor diagnostic facilities, and cost of molecular diagnosis (for screening purposes) result in interpretation of these subjects as normal. METHODS: Venous blood samples from 200 unmarried females having a family history of thalassemia were collected, and basic hematological parameters, hemoglobin electrophoresis, and molecular analysis for beta thalassemia were done. Patients with IDA and patients with co-pathological conditions BTT and IDA were treated with oral iron. These subjects were then followed for a period of 20 weeks. RESULTS: Of the 200 females, 34 were found to be anemic. Hemoglobin electrophoresis identified 16 of these patients as BTT. Molecular analysis of all patients confirmed this diagnosis, but identified 8 additional patients with BTT. Eight patients that were not detected with hemoglobin electrophoresis were found to have co-pathology of BTT with IDA. CONCLUSION: Patients with the co-pathological condition BTT with IDA may be interpreted as being normal, as they have normal Hb-A(2) levels. These misdiagnosed subjects when marry with BTT have the potential to produce beta thalassemia major in offspring. This is one of the factors playing a major role in the propagation of beta thalassemia gene in Pakistani population, and become a serious hindrance for the thalassemia prevention program in Pakistan. |
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Authors:
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Muhammad Usman; Moinuddin Moinuddin; Syed Azhar Ahmed |
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Publication Detail:
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Type: Journal Article Date: 2011-03-15 |
Journal Detail:
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Title: The Korean journal of hematology Volume: 46 ISSN: 2092-9129 ISO Abbreviation: Korean J Hematol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101486388 Medline TA: Korean J Hematol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: - |
Affiliation:
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Institute of Hematology, Baqai Medical University, Karachi, Pakistan. |
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