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Role of iron deficiency anemia in the propagation of beta thalssemia gene.
MedLine Citation:
PMID:  21461303     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The diagnostic criterion for beta thalassemia trait (BTT) is elevated Hb-A(2) levels. Iron deficiency anemia (IDA) reduces the synthesis of Hb-A(2), resulting in reduced Hb-A(2) levels, so patients with co-pathological conditions BTT with IDA, may have a normal level of Hb-A(2). Many socio-economic factors like unawareness, poor diagnostic facilities, and cost of molecular diagnosis (for screening purposes) result in interpretation of these subjects as normal.
METHODS: Venous blood samples from 200 unmarried females having a family history of thalassemia were collected, and basic hematological parameters, hemoglobin electrophoresis, and molecular analysis for beta thalassemia were done. Patients with IDA and patients with co-pathological conditions BTT and IDA were treated with oral iron. These subjects were then followed for a period of 20 weeks.
RESULTS: Of the 200 females, 34 were found to be anemic. Hemoglobin electrophoresis identified 16 of these patients as BTT. Molecular analysis of all patients confirmed this diagnosis, but identified 8 additional patients with BTT. Eight patients that were not detected with hemoglobin electrophoresis were found to have co-pathology of BTT with IDA.
CONCLUSION: Patients with the co-pathological condition BTT with IDA may be interpreted as being normal, as they have normal Hb-A(2) levels. These misdiagnosed subjects when marry with BTT have the potential to produce beta thalassemia major in offspring. This is one of the factors playing a major role in the propagation of beta thalassemia gene in Pakistani population, and become a serious hindrance for the thalassemia prevention program in Pakistan.
Authors:
Muhammad Usman; Moinuddin Moinuddin; Syed Azhar Ahmed
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Publication Detail:
Type:  Journal Article     Date:  2011-03-15
Journal Detail:
Title:  The Korean journal of hematology     Volume:  46     ISSN:  2092-9129     ISO Abbreviation:  Korean J Hematol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101486388     Medline TA:  Korean J Hematol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  -    
Affiliation:
Institute of Hematology, Baqai Medical University, Karachi, Pakistan.
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