Document Detail


Role of intravitreal bevacizumab in adult onset Coats' disease.
MedLine Citation:
PMID:  21437759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the role of intravitreal bevacizumab in the treatment of Coats' disease diagnosed in adulthood. Prospective, interventional case series. Three patients with Coats' disease diagnosed in adulthood were managed with a single intravitreal injection of bevacizumab (1.25 mg) with peripheral laser photocoagulation 3 weeks later. All three patients had exudation at the macula (Stage 2B) along with peripheral retinal telangiectasia and aneurysms. They were followed up for 9 months. An appreciable reduction in the exudation at the macula and macular edema was observed in all cases following intravitreal bevacizumab therapy. In all patients, the visual acuity improved, and no signs of recurrence were observed at the final follow-up at 9 months. Intravitreal bevacizumab injections may be effective as an adjunctive treatment for adult-onset Coats' disease with foveal exudation along with laser photocoagulation to the peripheral retinal vascular abnormalities. Intravitreal bevacizumab was well tolerated by our patients, and no adverse effects were observed.
Authors:
Neha Goel; Vinod Kumar; Anisha Seth; Usha Kaul Raina; Basudeb Ghosh
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-03-25
Journal Detail:
Title:  International ophthalmology     Volume:  31     ISSN:  1573-2630     ISO Abbreviation:  Int Ophthalmol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-15     Completed Date:  2011-12-06     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7904294     Medline TA:  Int Ophthalmol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Affiliation:
Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India. nehadoc@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiogenesis Inhibitors / administration & dosage*
Antibodies, Monoclonal, Humanized / administration & dosage*
Dose-Response Relationship, Drug
Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Intravitreal Injections
Laser Therapy / methods
Macula Lutea / drug effects,  pathology
Male
Middle Aged
Retinal Telangiectasis / drug therapy*,  pathology,  surgery
Time Factors
Tomography, Optical Coherence
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V/bevacizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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