Document Detail

Role of intravenous naloxone in severe pruritus of acute cholestasis.
MedLine Citation:
PMID:  20107967     Owner:  NLM     Status:  MEDLINE    
Pruritus is a well-known manifestation of various cholestatic disorders. Increased opioidergic tone is one of the mechanisms for this. This prospective, uncontrolled study was done to determine the efficacy of intravenous naloxone in pruritus of acute cholestasis. Twenty-two patients with severe pruritus (based on visual analogue scale [VAS] score of 0-100 and associated symptoms) were treated with intravenous naloxone (0.4 mg every 8 hours) for at least 48 hours. Viral hepatitis E was found to be the most common etiology for cholestatic pruritus (n=12). Eighteen patients (81.8%) patients had significant reduction in VAS after 48 hours of starting naloxone; these patients also showed reduction in alkaline phosphatase and gamma glutamyl transpeptidase. There was no side-effect or 'breakthrough' phenomenon noted in any patient over next 6 weeks. Naloxone is safe and efficacious in symptomatic improvement in cholestatic pruritus.
Gunjan G Joshi; B S Thakur; Shohini Sircar; Arvind Namdeo; Ajay K Jain
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Publication Detail:
Type:  Journal Article     Date:  2010-01-27
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  28     ISSN:  0975-0711     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-05-06     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  180-2     Citation Subset:  IM    
Department of Gastroenterology, Choithram Hospital and Research Centre, Indore, 452 014, India.
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MeSH Terms
Acute Disease
Cholestasis / complications*
Injections, Intravenous
Naloxone / administration & dosage*
Prospective Studies
Pruritus / drug therapy*,  etiology*
Reg. No./Substance:

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