| Role of intravenous levetiracetam in acute seizure management of children. | |
| | |
MedLine Citation:
|
PMID: 19520272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Status epilepticus is defined as a seizure lasting beyond 30 minutes. Children with intractable epilepsy undergo frequent hospital admissions secondary to status epilepticus or because of acute exacerbation of seizures. Intravenous levetiracetam became available in August 2006 for use in patients aged above 16 years. There are insufficient data about the efficacy and safety of intravenous levetiracetam in children. We retrospectively analyzed data from children treated with intravenous levetiracetam for status epilepticus and acute exacerbation of seizures. We acquired data from our institution's electronic medical records concerning patients with status epilepticus and acute exacerbation of seizures who received intravenous levetiracetam. Thirty-two patients (age range, 2 months to 18 years) had received a levetiracetam load of 25-50 mg/kg for status epilepticus. There were 17 (53.1%) males and 15 (46.8%) females. Response to intravenous levetiracetam in all patients was favorable. Status epilepticus ceased clinically and electrographically. Eighteen patients (56.5%) received intravenous levetiracetam after receiving fosphenytoin and Ativan with no response. No serious side effects were evident. Fifteen patients (46.8%) were discharged on levetiracetam monotherapy, and 9 (28.1%) received levetiracetam as adjunctive therapy after discharge from the hospital. Intravenous levetiracetam can be used adjunctively or as monotherapy in children with status epilepticus and acute exacerbation of seizures. |
| | |
Authors:
|
Batool F Kirmani; Edwin D Crisp; Saima Kayani; Hasan Rajab |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatric neurology Volume: 41 ISSN: 1873-5150 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-12 Completed Date: 2009-08-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 37-9 Citation Subset: IM |
Affiliation:
|
Epilepsy Center, Department of Neurology, Scott and White Neuroscience Institute, Temple, Texas 76508, USA. bkirmani@swmail.sw.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Anticonvulsants / administration & dosage* Brain / drug effects, physiopathology Chemotherapy, Adjuvant Child Child, Preschool Electroencephalography Female Humans Infant Infusions, Intravenous Male Piracetam / administration & dosage, analogs & derivatives* Retrospective Studies Seizures / drug therapy*, etiology, physiopathology Status Epilepticus / drug therapy*, etiology, physiopathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 33996-58-6/etiracetam; 7491-74-9/Piracetam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Celiac disease-related antibodies in Italian children with epilepsy.
Next Document: Congenital myasthenic syndrome with episodic apnea.