Document Detail

Role of intrahypothalamic insulin in circadian patterns of food intake, activity, and body temperature.
MedLine Citation:
PMID:  1590956     Owner:  NLM     Status:  MEDLINE    
These experiments examined the extent to which chronic intrahypothalamic (IH) insulin infusions that alter circadian patterns of food intake (FI) affect the regulation of other diurnally varying behavior in the rat. One-week IH insulin infusion (1.5 microU/hr) significantly decreases rats' night FI and increases day FI but does not alter the diurnal pattern of activity. Mean daily core temperature increased slightly but significantly during insulin infusion, the daily peak of the body temperature rhythm did not shift significantly, and the daily range of body temperature increased. IH insulin infusion in rats living in constant light and thus without circadian rhythm of FI led to significant decreases in FI and body weight. These data support the conclusion that IH insulin infusion alters food intake and body weight through a specific effect on a neural system that regulates food intake and body weight, and not by altering circadian rhythms.
M K McGowan; K M Andrews; S P Grossman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  106     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-01     Completed Date:  1992-07-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  380-5     Citation Subset:  IM    
Committee on Biopsychology, University of Chicago.
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MeSH Terms
Body Temperature Regulation / drug effects*
Body Weight / drug effects
Brain Mapping
Circadian Rhythm / drug effects*
Feeding Behavior / drug effects*
Hypothalamus / drug effects*
Insulin / pharmacology*
Insulin Infusion Systems
Motor Activity / drug effects*
Rats, Inbred Strains
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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