Document Detail


Role of interleukin-8 in differentiation of uncomplicated from complicated parapneumonic effusion.
MedLine Citation:
PMID:  21822181     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
(Full text is available at http://www.manu.edu.mk/prilozi). The aim of this study was to investigate the value and significance of interleukin-8 in differentiation of uncomplicated parapneumonic effusion (UCPPE) from complicated parapneumonic effusion (CPPE). Using an IMMULITE 1000 Analyzer, with chemiluminescent immunometric assay, levels of interleukin-8 (IL-8) were measured in the pleural fluid of patients with UCPPE (n = 30), and CPPE (n = 30), and three classical parameters (pH, glucose, and LDH) in these two groups. Receiver-operating curves were to assess the sensitivity and specifity of interleukin-8 for differentiating between the two patient groups. IL-8 levels were statistically higher in the CPPE group. A positive significant correlation, was found between levels of IL-8 and and lactate dehydrogenase (LDH) (r = 0.68, p < 0.05). There was also a positive significant correlation between IL-8 and protein level in pleural effusion (r = 0.306, r < 0.01). There was a significant negative correlation between levels of IL-8 and pH (r = - 0.83, p < 0.05), and of IL-8 and glucose in pleural fluid (r = - 0.61, p < 0.05). A cut-off value of 1805.81 pg/ml, differentiated CPPE from UPPE with a sensitivity of 100% and a specifity of 98%. IL-8 may be used as an alternative marker for the complication of parapneumonic effusion. Key words: uncomplicated parapneumonic effusion (UCPPE), complicated parapneumonic effusion (CPPE), cytokin, interleukin-8.
Authors:
S Petrusevska Marinkovic; I Kondova Topuzovska; Z Milenkovic; G Kondov; G Bosevska; A Anastasovska
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prilozi / Makedonska akademija na naukite i umetnostite, Oddelenie za biološki i medicinski nauki = Contributions / Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences     Volume:  32     ISSN:  0351-3254     ISO Abbreviation:  Prilozi     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-08-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189513     Medline TA:  Prilozi     Country:  Macedonia    
Other Details:
Languages:  eng     Pagination:  101-11     Citation Subset:  IM    
Affiliation:
Infectious Diseases Clinic, Clinical Centre, Medical Faculty, Skopje, R. Macedonia.
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