| Role of integrated PET-CT in pelvic lymph node staging of cervical cancer before radical hysterectomy. | |
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MedLine Citation:
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PMID: 18843187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To investigate the feasibility of preoperative integrated positron emission tomography-computed tomography (PET-CT) with fluoro-2-deoxy-D-glucose (FDG) in primary pelvic lymph node (LN) staging before radical hysterectomy (RH) and pelvic lymphadenectomy (PLND) in cervical cancer. METHODS: We reviewed medical records of all patients with FIGO stage IA2-IIB cervical cancer who underwent a preoperative FDG PET-CT and underwent type II or III RH and PLND between January 1, 2003, and July 31, 2007. RESULTS: A total of 34 patients underwent preoperative PET-CT scans followed by RH and PLND during the study period. Of the 34 patients, 17 (50.0%) had pelvic LN metastases, and the median number of harvested LNs was 29 (range 13-57). The overall region-specific sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET-CT were 36.4, 98.8, 85.7, 88.9, and 88.7%, respectively. The patients with positive preoperative PET-CT scans showed higher recurrence rates (3/8) than those with negative scans (1/26); the difference was statistically significant (p = 0.031). CONCLUSION: Integrated PET-CT scan has limited sensitivity, but high specificity for predicting pelvic LN metastasis in preoperative staging of invasive cervical cancer. Furthermore, preoperative integrated PET-CT may be a useful tool for identifying patients with higher risk of cervical cancer recurrence. |
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Authors:
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Hyun Hoon Chung; Noh-Hyun Park; Jae Weon Kim; Yong-Sang Song; June-Key Chung; Soon-Beom Kang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-09 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 67 ISSN: 1423-002X ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 61-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Hysterectomy Lymph Node Excision Lymph Nodes / pathology*, radionuclide imaging, surgery Lymphatic Metastasis Middle Aged Neoplasm Staging Positron-Emission Tomography / methods* Predictive Value of Tests Reproducibility of Results Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed / methods* Uterine Cervical Neoplasms / pathology*, radionuclide imaging, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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