Document Detail


Role of integrated PET-CT in pelvic lymph node staging of cervical cancer before radical hysterectomy.
MedLine Citation:
PMID:  18843187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To investigate the feasibility of preoperative integrated positron emission tomography-computed tomography (PET-CT) with fluoro-2-deoxy-D-glucose (FDG) in primary pelvic lymph node (LN) staging before radical hysterectomy (RH) and pelvic lymphadenectomy (PLND) in cervical cancer. METHODS: We reviewed medical records of all patients with FIGO stage IA2-IIB cervical cancer who underwent a preoperative FDG PET-CT and underwent type II or III RH and PLND between January 1, 2003, and July 31, 2007. RESULTS: A total of 34 patients underwent preoperative PET-CT scans followed by RH and PLND during the study period. Of the 34 patients, 17 (50.0%) had pelvic LN metastases, and the median number of harvested LNs was 29 (range 13-57). The overall region-specific sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET-CT were 36.4, 98.8, 85.7, 88.9, and 88.7%, respectively. The patients with positive preoperative PET-CT scans showed higher recurrence rates (3/8) than those with negative scans (1/26); the difference was statistically significant (p = 0.031). CONCLUSION: Integrated PET-CT scan has limited sensitivity, but high specificity for predicting pelvic LN metastasis in preoperative staging of invasive cervical cancer. Furthermore, preoperative integrated PET-CT may be a useful tool for identifying patients with higher risk of cervical cancer recurrence.
Authors:
Hyun Hoon Chung; Noh-Hyun Park; Jae Weon Kim; Yong-Sang Song; June-Key Chung; Soon-Beom Kang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-09
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  67     ISSN:  1423-002X     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Humans
Hysterectomy
Lymph Node Excision
Lymph Nodes / pathology*,  radionuclide imaging,  surgery
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Positron-Emission Tomography / methods*
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed / methods*
Uterine Cervical Neoplasms / pathology*,  radionuclide imaging,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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