Document Detail


Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis.
MedLine Citation:
PMID:  21641553     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydroxylase (Th)-expressing cells of mice (IR(ΔTh)). IR inactivation in Th-expressing cells of mice resulted in increased body weight, increased fat mass, and hyperphagia. While insulin acutely stimulated firing frequency in 50% of dopaminergic VTA/SN neurons, this response was abolished in IR(ΔTh) mice. Moreover, these mice exhibited an altered response to cocaine under food-restricted conditions. Taken together, these data provide in vivo evidence for a critical role of insulin signaling in catecholaminergic neurons to control food intake and energy homeostasis.
Authors:
A Christine Könner; Simon Hess; Sulay Tovar; Andrea Mesaros; Carmen Sánchez-Lasheras; Nadine Evers; Linda A W Verhagen; Hella S Brönneke; André Kleinridders; Brigitte Hampel; Peter Kloppenburg; Jens C Brüning
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell metabolism     Volume:  13     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Center of Molecular Medicine Cologne, University of Cologne, D-50674 Cologne, Germany; Max Planck Institute for Neurological Research, D-50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, D-50924 Cologne, Germany.
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