Document Detail


Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis.
MedLine Citation:
PMID:  10699960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interest in the role of the insulin-like growth factor (IGF) axis in growth control and carcinogenesis has recently been increased by the finding of elevated serum insulin-like growth factor I (IGF-I) levels in association with three of the most prevalent cancers in the United States: prostate cancer, colorectal cancer, and lung cancer. IGFs serve as endocrine, autocrine, and paracrine stimulators of mitogenesis, survival, and cellular transformation. These actions are mediated through the type 1 IGF-receptor (IGF-1R), a tyrosine kinase that resembles the insulin receptor. The availability of free IGF for interaction with the IGF-1R is modulated by the insulin-like growth factor-binding proteins (IGFBPs). IGFBPs, especially IGFBP-3, also have IGF-independent effects on cell growth. IGF-independent growth inhibition by IGFBP-3 is believed to occur through IGFBP-3-specific cell surface association proteins or receptors and involves nuclear translocation. IGFBP-3-mediated apoptosis is controlled by numerous cell cycle regulators in both normal and disease processes. IGFBP activity is also regulated by IGFBP proteases, which affect the relative affinities of IGFBPs, IGFs and IGF-1R. Perturbations in each level of the IGF axis have been implicated in cancer formation and progression in various cell types.
Authors:
A Grimberg; P Cohen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  183     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-03-29     Completed Date:  2000-03-29     Revised Date:  2014-08-27    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division / physiology*
Colorectal Neoplasms / physiopathology
Humans
Insulin-Like Growth Factor Binding Protein 3 / physiology
Insulin-Like Growth Factor Binding Proteins / physiology*
Insulin-Like Growth Factor I / physiology*
Lung Neoplasms / physiopathology
Male
Neoplasms / pathology,  physiopathology*
Prostatic Neoplasms / physiopathology
Receptor, IGF Type 1 / physiology*
Grant Support
ID/Acronym/Agency:
1P50HL56401/HL/NHLBI NIH HHS; 1RO1AI40203/AI/NIAID NIH HHS; 2RO1DK47591/DK/NIDDK NIH HHS; R01 AI040203/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 3; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I; EC 2.7.10.1/Receptor, IGF Type 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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