Document Detail

Role of insulin-like growth factor binding protein 1 in human pregnancy.
MedLine Citation:
PMID:  10521153     Owner:  NLM     Status:  MEDLINE    
Insulin-like growth factors and their binding proteins are key regulators of fetal and maternal tissue growth and development during human pregnancy. Insulin-like growth factors, particularly IGF-II, are produced in abundance by the trophoblast cells of the placenta, whereas one of the insulin-like growth factor binding proteins, IGFBP-1, is the major secretory product of the maternal decidualized endometrium. This spatial (and temporal expression) of the insulin-like growth factor axis infers a sophisticated paracrine regulatory mechanism for controlling insulin-like growth factor function. This paper reviews the potential roles of IGFBP-1 in human pregnancy by examining its effects on growth, metabolism and migration at the maternal-fetal interface and how these might be influenced by autocrine-paracrine post-translational modifications.
M Westwood
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of reproduction     Volume:  4     ISSN:  1359-6004     ISO Abbreviation:  Rev. Reprod.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9602351     Medline TA:  Rev Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  160-7     Citation Subset:  IM    
Department of Medicine, University of Manchester, UK.
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MeSH Terms
Autocrine Communication
Embryonic and Fetal Development / physiology
Insulin-Like Growth Factor Binding Protein 1 / physiology*
Maternal-Fetal Exchange / physiology*
Paracrine Communication
Pregnancy Proteins / physiology*
Protein Processing, Post-Translational
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 1; 0/Pregnancy Proteins

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