| Role of insulin and IGF-I on the regulation of glucose metabolism in European sea bass (Dicentrarchus labrax) fed with different dietary carbohydrate levels. | |
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MedLine Citation:
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PMID: 20696267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The roles of insulin and insulin-like growth factor-I (IGF-I) in the regulation of glucose metabolism were assessed in European sea bass juveniles fed with distinct dietary carbohydrate levels. Three isonitrogenous diets were formulated to contain 10% (10%PGS) or 30% (30%PGS) pregelatinized starch or no starch (control). The highest plasma glucose and insulin levels were observed 6h after feeding in fish receiving the 30%PGS diet. Although plasma IGF-I was higher at 6h than at 24h after feeding, no effect of dietary carbohydrate level was noticed within each sampling time. Increasing dietary carbohydrate level resulted in an increase of liver but not of muscle glycogen content. Hepatic glucokinase (GK) and glucose-6-phosphate dehydrogenase (G6PD) activities increased with the dietary carbohydrate content, whereas pyruvate kinase (PK) activity was higher in fish fed the carbohydrate containing diets than the carbohydrate-free diet. GK activity was higher 6h than 24h after feeding, whereas the opposite was observed for G6PD activity. Data suggest that under the nutritional conditions assayed plasma glucose is an insulin secretagogue. Furthermore, insulin appears to have a more important role than IGF-I in stimulating hepatic glucose uptake, thus enhancing GK activity and leading to an increase in liver glycogen content to maintain glucose homeostasis. |
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Authors:
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P Enes; J Sanchez-Gurmaches; I Navarro; J Gutiérrez; A Oliva-Teles |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-07 |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 157 ISSN: 1531-4332 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 346-53 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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CIMAR/CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. enes@portugalmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bass / blood, growth & development, metabolism* Blood Glucose / drug effects, metabolism* Diet Dietary Carbohydrates / administration & dosage*, pharmacology* Europe Feeding Behavior / drug effects* Insulin / blood, metabolism* Insulin-Like Growth Factor I / metabolism* Liver / drug effects, enzymology Muscles / drug effects, metabolism Radioimmunoassay Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Carbohydrates; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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