| Role of innate immunity and the microbiota in liver fibrosis - Crosstalk between the liver and gut. | |
| | |
MedLine Citation:
|
PMID: 22124143 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Liver fibrosis occurs as a wound-healing scar response following chronic liver inflammation including alcoholic liver disease, non-alcoholic steatohepatitis, viral hepatitis, cholestatic liver disease and autoimmune liver diseases. The liver has a unique vascular system within the gastrointestinal tract, as the majority of the liver's blood supply comes from the intestine through the portal vein. When the intestinal barrier function is disrupted, an increase in intestinal permeability leads to the translocation of intestine-derived bacterial products such as lipopolysaccharide (LPS) and unmethylated CpG containing DNA to the liver via the portal vein. These gut-derived bacterial products stimulate innate immune receptors, namely Toll-like receptors (TLRs), in the liver. TLRs are expressed on Kupffer cells, endothelial cells, dendritic cells, biliary epithelial cells, hepatic stellate cells, and hepatocytes. TLRs activate these cells to contribute to acute and chronic liver diseases. This review summarizes recent studies investigating the role of TLRs, intestinal microbiota and bacterial translocation in liver fibrosis, alcoholic liver disease and non-alcoholic steatohepatitis. |
| | |
Authors:
|
Ekihiro Seki; Bernd Schnabl |
Related Documents
:
|
12162873 - Expression and modulation of ifn-gamma-inducible chemokines (ip-10, mig, and i-tac) in ... 16775323 - Suppression of the interferon-mediated innate immune response by pseudorabies virus. 20083193 - Linking oxidative stress to inflammation: toll-like receptors. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-28 |
Journal Detail:
|
Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of California San Diego. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Early Release of Planned Movement by Acoustic Startle Can be Delayedby Transcranial Magnetic Sti...
Next Document: Regulation of hippocampal inhibitory circuits by nicotinic acetylcholine receptors.