Document Detail


Role of innate immunity in cardiac inflammation after myocardial infarction .
MedLine Citation:
PMID:  23277038     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Over the past two decades, inflammation has emerged as a key pathophysiological process during myocardial infarction. It develops consecutively to the activation of innate immune defense mechanisms, in response to the release of endogenous molecules by necrotic cells and the extracellular matrix. These danger signals are sensed by cellular receptors normally involved in antimicrobial defenses, including toll-like receptors and a subset of NOD-like receptors, which promote intracellular signaling dependent on nuclear factor kappaB and on the formation of the inflammasome. These mechanisms stimulate the expression of multiple inflammatory mediators and growth factors, sequentially inducing the recruitment of inflammatory cells, the clearance of injured tissue, angiogenesis, and the proliferation of fibroblasts, eventually resulting in scar formation and infarct healing. Dysregulation of these responses may result in continued cardiomyocyte loss, fibrosis beyond the limits of the infarcted area, reactive hypertrophy and chamber dilatation, a process termed adverse cardiac remodeling, leading to functional compromise and heart failure. This review presents the current state of knowledge on the process of immune activation within the infarcted myocardium and its consequences.
Authors:
Lucas Liaudet; Nathalie Rosenblatt-Velin
Related Documents :
24361318 - In vivo silencing of the transcription factor irf5 reprograms the macrophage phenotype ...
24776498 - Assessment of left ventricular dyssynchrony by real-time three-dimensional echocardiogr...
24048008 - Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of ...
20479658 - A new post-pci scoring system for in-hospital mortality in stemi patients.
4031288 - Smoke-like echo in the left atrial cavity in mitral valve disease: its features and sig...
24748878 - Long term outcomes of saphaneous vein graft intervention in elderly patients with prior...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-104     Citation Subset:  IM    
Affiliation:
Department of Intensive Care Medicine and Burn Center, University Hospital Medical Center, Faculty of Biology and Medicine, Lausanne-1010, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of WWOX/WOX1 in Alzheimer's disease pathology and in cell death signaling .
Next Document:  The role of innate signals in B cell immunity to influenza virus .