Document Detail

Role of the innate immune system in the pathogenesis of inflammatory bowel disease.
MedLine Citation:
PMID:  19179875     Owner:  NLM     Status:  MEDLINE    
Crohn disease and ulcerative colitis are chronic inflammatory diseases of the intestinal tract commonly denoted as inflammatory bowel diseases. It has been proposed that these diseases result from aberrant mucosal immune responses to nonpathogenic microbial residents of the intestines. Recently, it was established that continuous interactions between the innate and the adaptive intestinal immune cells and the microbiota are directly involved in maintaining the physiological noninflammatory state of the intestinal mucosa. In light of the complexity of this mucosal homeostasis, it is astonishing that the inflammatory bowel diseases are relatively rare. Recently, altered functions of the innate immune system have been identified. As such, both hyperresponsiveness and hyporesponsiveness of innate cells have been implicated in the pathogenesis of inflammatory bowel diseases.
Pieter P E van Lierop; Janneke N Samsom; Johanna C Escher; Edward E S Nieuwenhuis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  48     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-30     Completed Date:  2009-06-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  142-51     Citation Subset:  IM    
Department of Pediatric Gastroenterology, Erasmus MC Sophia Children's Hospital-University Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Antibody Formation / immunology,  physiology*
Bacterial Physiological Phenomena
Colitis, Ulcerative / immunology,  microbiology
Crohn Disease / immunology,  microbiology
Immunity, Innate / immunology,  physiology*
Inflammatory Bowel Diseases / immunology*,  microbiology*
Intestinal Mucosa / immunology
Receptors, Pattern Recognition / immunology*
Reg. No./Substance:
0/Receptors, Pattern Recognition

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