Document Detail

Role of inhaled tiotropium on the perioperative outcomes of patients with lung cancer and chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  20072975     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tiotropium, a long-acting bronchodilator, can be used perioperatively in patients with lung cancer and airway obstruction, although its benefits for the perioperative outcome remain unclear. METHODS: We prospectively collected the perioperative data of 44 patients with resectable lung cancer and untreated airway obstruction. Tiotropium was not used before September 2007 (control group, n = 24) but was used routinely thereafter (treated group, n = 20). We estimated a propensity score to adjust comparisons between the groups. RESULTS: Tiotropium improved preoperative global pulmonary function significantly, especially in four patients. Postoperative outcomes in these major responders were significantly better than those in the remaining minor responders. However, postoperative outcomes were not significantly different between the treated group (n = 15) and the control group (n = 15) matched by a propensity score. CONCLUSION: Regardless of its favorable effects on preoperative pulmonary function, we could not establish a significant benefit of tiotropium for postoperative outcomes overall. Nonetheless, our data suggested that tiotropium might have improved the postoperative outcomes of major responders.
K Ueda; T Tanaka; M Hayashi; K Hamano
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2010-01-13
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  58     ISSN:  1439-1902     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-14     Completed Date:  2010-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
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MeSH Terms
Administration, Inhalation
Aged, 80 and over
Bronchodilator Agents / administration & dosage*
Lung Neoplasms / drug therapy*
Perioperative Care*
Pulmonary Disease, Chronic Obstructive / drug therapy*
Respiratory Function Tests
Scopolamine Derivatives / administration & dosage*
Treatment Outcome
Reg. No./Substance:
0/Bronchodilator Agents; 0/Scopolamine Derivatives; 136310-93-5/tiotropium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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