| Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase. | |
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MedLine Citation:
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PMID: 19787194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isaac's syndrome is a movement disorder characterized by hyperexcitability of peripheral motor nerves. Patients with Isaac's syndrome often develop auto-antibodies to voltage-gated potassium channels (VGKCs) which block their function. However, anti-VGKC antibodies are not detected in all patients with Isaac's syndrome, suggesting the existence of another etiology. In this study, we performed immunoscreening using the serum from a patient with Isaac's syndrome and identified the novel gene named Kenae/CCDC125. Expression analysis of Kenae/CCDC125 revealed that its transcript was highly expressed in tissues associated with the immune system, such as the thymus, spleen and bone marrow. In cells stably expressing Kenae/CCDC125, delay in cell motility and deregulation of RhoGTPase (RhoA, Rac1 and cdc42) activity to extracellular stimuli were demonstrated. These results suggest that the novel gene, Kenae/CCDC125, acts as a regulator of cell motility through RhoA, Rac1 and cdc42. |
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Authors:
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Natsumi Araya; Hitoshi Arimura; Ko-ichi Kawahara; Naoko Yagishita; Junji Ishida; Ryoji Fujii; Satoko Aratani; Hidetoshi Fujita; Tomoo Sato; Yoshihisa Yamano; Itsuro Higuchi; Mitsuhiro Osame; Kusuki Nishioka; Akiyoshi Fukamizu; Kimiyoshi Arimura; Ikuro Maruyama; Toshihiro Nakajima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of molecular medicine Volume: 24 ISSN: 1791-244X ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 605-11 Citation Subset: IM |
Affiliation:
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Department of Genome Science, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AB024691 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antigens / blood Base Sequence Cell Line, Tumor Cell Movement* Cloning, Molecular GTPase-Activating Proteins / metabolism* Gene Expression Profiling Gene Expression Regulation Humans Isaacs Syndrome / blood, metabolism Mice Molecular Sequence Data Proteins / chemistry, genetics, metabolism* RNA, Messenger / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/CCDC125 protein, human; 0/CCDC125 protein, mouse; 0/GTPase-Activating Proteins; 0/Proteins; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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