| Role of CCN2/CTGF/Hcs24 in bone growth. | |
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MedLine Citation:
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PMID: 17280894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our bones mostly develop through a process called endochondral ossification. This process is initiated in the cartilage prototype of each bone and continues through embryonic and postnatal development until the end of skeletal growth. Therefore, the central regulator of endochondral ossification is the director of body construction, which is, in other words, the determinant of skeletal size and shape. We suggest that CCN2/CTGF/Hcs24 (CCN2) is a molecule that conducts all of the procedures of endochondral ossification. CCN2, a member of the CCN family of novel modulator proteins, displays multiple functions by manipulating the local information network, using its conserved modules as an interface with a variety of other biomolecules. Under a precisely designed four-dimensional genetic program, CCN2 is produced from a limited population of chondrocytes and acts on all of the mesenchymal cells inside the bone callus to promote the integrated growth of the bone. Furthermore, the utility of CCN2 as regenerative therapeutics against connective tissue disorders, such as bone and cartilage defects and osteoarthritis, has been suggested. Over the years, the pathological action of CCN2 has been suggested. Nevertheless, it can also be regarded as another aspect of the physiological and regenerative function of CCN2, which is discussed as well. |
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Authors:
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Satoshi Kubota; Masaharu Takigawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: International review of cytology Volume: 257 ISSN: 0074-7696 ISO Abbreviation: Int. Rev. Cytol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-02-06 Completed Date: 2007-06-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985180R Medline TA: Int Rev Cytol Country: United States |
Other Details:
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Languages: eng Pagination: 1-41 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Development / physiology* Connective Tissue Growth Factor Humans Immediate-Early Proteins / chemistry, genetics, metabolism* Intercellular Signaling Peptides and Proteins / chemistry, genetics, metabolism* Mesoderm / metabolism Osteocytes / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/CTGF protein, human; 0/Immediate-Early Proteins; 0/Intercellular Signaling Peptides and Proteins; 139568-91-5/Connective Tissue Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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