Document Detail


Role of exosomes/microvesicles in the nervous system and use in emerging therapies.
MedLine Citation:
PMID:  22754538     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Extracellular membrane vesicles (EMVs) are nanometer sized vesicles, including exosomes and microvesicles capable of transferring DNAs, mRNAs, microRNAs, non-coding RNAs, proteins, and lipids among cells without direct cell-to-cell contact, thereby representing a novel form of intercellular communication. Many cells in the nervous system have been shown to release EMVs, implicating their active roles in development, function, and pathologies of this system. While substantial progress has been made in understanding the biogenesis, biophysical properties, and involvement of EMVs in diseases, relatively less information is known about their biological function in the normal nervous system. In addition, since EMVs are endogenous vehicles with low immunogenicity, they have also been actively investigated for the delivery of therapeutic genes/molecules in treatment of cancer and neurological diseases. The present review summarizes current knowledge about EMV functions in the nervous system under both physiological and pathological conditions, as well as emerging EMV-based therapies that could be applied to the nervous system in the foreseeable future.
Authors:
Charles Pin-Kuang Lai; Xandra Owen Breakefield
Related Documents :
6542868 - Synchronization of oxytocin cells in the hypothalamic paraventricular and supraoptic nu...
21695798 - Microfabrication of pdlla scaffolds.
21878748 - Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination ...
21854258 - Effects of bmps on primary human renal cells and the generation of bmp-7-expressing cel...
7440648 - The effects of 5-bromodeoxyuridine on the growth and morphology of transformed rat live...
9112408 - The fas system is a key regulator of germ cell apoptosis in the testis.
Publication Detail:
Type:  Journal Article     Date:  2012-06-27
Journal Detail:
Title:  Frontiers in physiology     Volume:  3     ISSN:  1664-042X     ISO Abbreviation:  Front Physiol     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-10-02     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101549006     Medline TA:  Front Physiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  228     Citation Subset:  -    
Affiliation:
Department of Neurology, Neuroscience Center, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mathematical and statistical modeling in cancer systems biology.
Next Document:  Plasmacytoid dendritic cells in atherosclerosis.