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Role of impaired glucose tolerance in patients with acute myocardial infarction in relation to sex.
MedLine Citation:
PMID:  24995511     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION  Impaired glucose tolerance (IGT) has a negative impact on the outcome of patients with acute myocardial infarction (AMI). OBJECTIVES Based on the result of oral glucose tolerance test 560 patients with IGT were selected out of a single center registry of 2733 consecutive patients with AMI (395 men, 165 women). Sex related mortality and major adverse cardiac events (MACEs) including myocardial re-infarction, stroke or revascularization during the index hospitalization as well as long-term follow-up were compared in the whole population with IGT and within its high-risk subgroups. RESULTS Mortality and MACE rates were comparable between men and women except for the higher stroke rate in women (4.8 vs 1.5%, P<0.05). No significant differences were observed in the subgroups with lowered ejection fraction <35% and age above 70 years old, during both short and long-term observation. In women however, higher total stroke rates were observed in the subgroup of patients with incomplete revascularization (6.9 vs 1.1%, P<0.05), while total mortality rates in the subgroup with renal dysfunction (40 vs 16%, P<0.05). Female sex was an independent risk factor for stroke (HR 2.94, P=0.048) and MACE (HR 1.45, P=0.009), but not for death in the population of patients with AMI and IGT. CONCLUSIONS Mortality in women and men with acute myocardial infarction treated with PCI with concomitant IGT is comparable, but female sex is an independent risk factor for stroke and MACE, particularly worsening prognosis in patients with renal dysfunction.
Authors:
Agnieszka Sędkowska; Jacek Kowalczyk; Aleksandra Woźniak; Tomasz Kurek; Teresa Zielińska; Krzysztof Strojek; Janusz Gumprecht; Zbigniew Kalarus
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-4
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnetrznej     Volume:  -     ISSN:  1897-9483     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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