Document Detail

Role of iNO in the modulation of pulmonary vascular resistance.
MedLine Citation:
PMID:  19057617     Owner:  NLM     Status:  MEDLINE    
Inhaled nitric oxide (iNO) has quickly become a standard therapy for term and near-term infants with hypoxic respiratory failure and persistent pulmonary hypertension. Its effect on the lung is believed to be through the stimulation of soluble guanylyl cyclase and the increased production of cyclic guanosine 3',5'-monophosphate (cGMP). However, in addition to pulmonary vasodilation and a decrease in pulmonary vascular resistance, nitric oxide (NO) shows several additional potential beneficial effects on the lung. This article reviews NO mechanisms of action, early clinical trial of iNO and clinical aspects for the use of iNO in acute respiratory failure of the term and near-tem neonates.
A Bin-Nun; M D Schreiber
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  28 Suppl 3     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S84-92     Citation Subset:  IM    
Department of Pediatrics, Section of Neonatology, The University of Chicago, Chicago, IL, USA.
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MeSH Terms
Administration, Inhalation
Bronchodilator Agents / pharmacology*,  therapeutic use
Infant, Newborn
Nitric Oxide / pharmacology*,  therapeutic use
Persistent Fetal Circulation Syndrome / drug therapy
Vascular Resistance / drug effects*
Reg. No./Substance:
0/Bronchodilator Agents; 10102-43-9/Nitric Oxide

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