| Role of hypoxic pulmonary vasoconstriction in pulmonary gas exchange and blood flow distribution. 2. Pathophysiology. | |
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MedLine Citation:
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PMID: 7930036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review, the second of a two part series, the analytic techniques introduced in the first part are applied to a broad range of pulmonary pathophysiologic conditions. The contributions of hypoxic pulmonary vasoconstriction to both homeostasis and pathophysiology are quantitated for atelectasis, pneumonia, sepsis, pulmonary embolism, chronic obstructive pulmonary disease and adult respiratory distress syndrome. For each disease state the influence of principle variables, including inspired oxygen concentration, cardiac output and severity of pathology are explored and the actions of selected drugs including inhaled nitric oxide and infused vasodilators are illustrated. It is concluded that hypoxic pulmonary vasoconstriction is often a critical determinant of hypoxemia and/or pulmonary hypertension. Furthermore this analysis demonstrates the value of computer simulation to reveal which of the many variables are most responsible for pathophysiologic results. |
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Authors:
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B E Marshall; C W Hanson; F Frasch; C Marshall |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Intensive care medicine Volume: 20 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-11-02 Completed Date: 1994-11-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 379-89 Citation Subset: IM |
Affiliation:
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Center for Anesthesia Research, University of Pennsylvania School of Medicine, Philadelphia 19104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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physiopathology* Humans Lung Diseases, Obstructive / physiopathology Pneumonia / physiopathology Pulmonary Artery / physiology* Pulmonary Atelectasis / physiopathology Pulmonary Circulation / physiology* Pulmonary Gas Exchange / physiology* Pulmonary Veins / physiology* Respiratory Distress Syndrome, Adult / physiopathology Vasoconstriction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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GM29628/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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