| Role of hypothermia in the production of gastric ulcers in a rat spinal cord transection model. | |
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MedLine Citation:
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PMID: 6109600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An association between hypothermia and gastric ulceration has been reported in rats in cervical cord section and in restraint models. The present study was designed to determine this relationship in cervical and in lumbar cord sectioned Sprague-Dawley rats. Ambient temperatures were varied by placing the sectioned animals in a room-temperature (23 degrees), incubator (28 degrees), or cold-room (4 degrees) environment for 8 hr. Rectal temperatures were recorded at the beginning and end of all experimental conditions. The endpoint of each study was the presence or absence of ulcers on naked eye examination. The length of each ulcer was measured and the lengths were totaled for each stomach. Cervical section rats became hypothermic at room temperature and developed extensive linear ulcerations of the glandular stomachs. A warm environment reduced both the decrement in core temperature and the degree of ulceration. Lumbar section rats only became hypothermic when exposed to cold and then developed significant ulcers. Hypothermia plays an important role in ulcerogenesis, but other factors are also important since not all the hypothermic rats developed ulcers and exposure of sham-operated rats to cold led to occasional pinpoint ulcer formation in spite of maintenance of a stable core temperature. |
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Authors:
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H H Sigman; A Gillich |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 26 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1981-04-13 Completed Date: 1981-04-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 60-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Animals Body Temperature Cold Temperature / adverse effects Hypothermia / complications* Rats Spinal Cord / physiology* Stomach Ulcer / etiology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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