| Role of hypothermia in the pentobarbital-induced blockade of luteinizing hormone secretion in female rats. | |
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MedLine Citation:
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PMID: 3658110 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were conducted to determine if the hypothermic effects of barbiturates were responsible for their ability to suppress luteinizing hormone (LH) secretion in rats following ovariectomy or treatment with gonadal steroids. In both ovariectomized rats and rats treated with estradiol and progesterone, pentobarbital caused a marked hypothermia and blocked LH hypersecretion. In ovariectomized rats, the LH-suppressing effects of pentobarbital could be prevented by maintaining normal core body temperature. However, in steroid-treated rats, the maintenance of normal core body temperature did not prevent the pentobarbital-induced blockade of the steroid-induced LH surge. These data indicate that the pentobarbital-induced reduction of LH secretion in ovariectomized rats is temperature-dependent, while its blockade of the steroid-induced LH surge is not. Additionally, this study provides further evidence for the differential neuronal regulation of LH secretion following ovariectomy and during the steroid-induced surge in LH. |
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Authors:
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J W Simpkins; M J Katovich |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroendocrinology Volume: 46 ISSN: 0028-3835 ISO Abbreviation: Neuroendocrinology Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0035665 Medline TA: Neuroendocrinology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 217-21 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Estradiol / pharmacology Female Hypothermia / chemically induced, physiopathology* Luteinizing Hormone / secretion* Ovariectomy Ovary / physiology Pentobarbital / pharmacology* Progesterone / pharmacology Rats |
| Grant Support | |
ID/Acronym/Agency:
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AG 02021/AG/NIA NIH HHS; HD 18133/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 57-83-0/Progesterone; 76-74-4/Pentobarbital; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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