| Role of hypothalamic alpha-adrenoceptor activity in fructose-induced hypertension. | |
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MedLine Citation:
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PMID: 17002666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to investigate the effects of the alpha2-adrenoceptor antagonist yohimbine on blood pressure and heart rate (HR) regulation, as well as on adrenergic and serotoninergic neurotransmission, in fructose hypertensive (F) rats. The anterior hypothalamic area of control (C) and F rats was perfused with Ringer's solution containing 10 and 100 microg/mL yohimbine through a microdialysis concentric probe. The effects of yohimbine on mean arterial pressure (MAP) and HR, as well as on hypothalamic dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole acetic acid (5-HIAA) levels, were measured according to perfusion time. Although intrahypothalamic perfusion of yohimbine increased blood pressure in C rats (DeltaMAP 9 +/- 1 and 11 +/- 2 mmHg for 10 and 100 microg/mL yohimbine, respectively; P < 0.05 vs Ringer's perfusion), the alpha-adrenoceptor antagonist did not modify MAP in F. Intrahypothalamic yohimbine had no effect on HR at either concentration tested. Intrahypothalamic perfusion of 10 and 100 microg/mL yohimbine increased DOPAC levels in C rats (135 +/- 6 and 130 +/- 5% of basal levels, respectively; both n = 6; P < 0.05 vs Ringer's perfusion), but not in F animals (115 +/- 6 and 102 +/- 6% of basal levels, respectively; both n = 6). In both C and F rats, yohimbine administration induced an increase in 5-HIAA dialysate levels. The results of the present study support the notion that alpha2-adrenoceptor tone of the anterior hypothalamus of normotensive rats, which contributes to normal blood pressure regulation, is not involved in the control of HR in either normotensive C or hypertensive F rats. The absence of changes in MAP after yohimbine perfusion in F rats suggests that the alpha2-adrenoceptor tone could be decreased in this group of rats and that this may be responsible for the maintenance of hypertension in this model. Intrahypothalamic perfusion of yohimbine increased DOPAC in the dialysate only in C rats, suggesting changes in presynaptic alpha2-adrenoceptor activity in fructose-overloaded rats. Conversely, increased 5-HIAA levels did not differ between C and F groups. |
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Authors:
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Marcos A Mayer; Christian Höcht; Javier Aw Opezzo; Horacio A Peredo; Daniel Navacchia; Carlos A Taira; Belisario E Fernández; Ana M Puyó |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 33 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-27 Completed Date: 2006-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 904-9 Citation Subset: IM |
Affiliation:
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Department of Macro and Microscopic Anatomy, University of Buenos Aires, Buenos Aires, Argentina. marcos.mayer@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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pharmacology Animals Anterior Hypothalamic Nucleus / drug effects Antibody Formation / drug effects Blood Pressure / drug effects Body Weight / drug effects Fructose* Heart / drug effects Heart Rate / drug effects Hydroxyindoleacetic Acid / pharmacology Hypertension / chemically induced* Hypothalamus / metabolism, physiology* Male Perfusion / methods Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha / metabolism*, physiology* Receptors, Serotonin / metabolism Synaptic Transmission / drug effects Yohimbine / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, alpha; 0/Receptors, Serotonin; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 146-48-5/Yohimbine; 30237-26-4/Fructose; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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