| Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia. | |
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MedLine Citation:
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PMID: 18945952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothalamic paraventricular nucleus (PVN) is an important integrative center in the brain. In the present study, we investigated whether the PVN is a key region in the mesenteric vasoconstriction that normally accompanies an increase in core body temperature. Anesthetized rats were monitored for blood pressure, heart rate, mesenteric blood flow, and vascular conductance. In control rats, elevation of core body temperature to 41 degrees C had no significant effect on blood pressure, increased heart rate, and reduced mesenteric blood flow by 21%. In a separate group of rats, muscimol was microinjected bilaterally (1 nmol/side) into the PVN. Compared with the control group, there was no significant difference in the blood pressure and heart rate responses elicited by the increase in core body temperature. In contrast to control animals, however, mesenteric blood flow did not fall in the muscimol-treated rats in response to the elevation in core body temperature. In a separate group, in which muscimol was microinjected into regions outside the PVN, elevating core body temperature elicited the normal reduction in mesenteric blood flow. The results suggest that the PVN may play a key role in the reflex decrease in mesenteric blood flow elicited by hyperthermia. |
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Authors:
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Feng Chen; Melissa Dworak; Yuliang Wang; Joo Lee Cham; Emilio Badoer |
Publication Detail:
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Type: Journal Article Date: 2008-10-22 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 295 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-10 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1874-81 Citation Subset: IM |
Affiliation:
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School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Melbourne, VIC, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Body Temperature Disease Models, Animal Down-Regulation Fever / physiopathology* GABA Agonists / administration & dosage Heart Rate Male Microinjections Muscimol / administration & dosage Paraventricular Hypothalamic Nucleus / drug effects, physiopathology* Rats Rats, Sprague-Dawley Receptors, GABA-A / agonists Reflex* / drug effects Regional Blood Flow Splanchnic Circulation* / drug effects Time Factors Vasoconstriction* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/GABA Agonists; 0/Receptors, GABA-A; 2763-96-4/Muscimol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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