| Role of hypertension in the progression of chronic renal disease. | |
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MedLine Citation:
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PMID: 11369824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension leads to renal disease through a series of mechanisms that seem to be exaggerated in African-Americans, who have a higher prevalence of both hypertension and end-stage renal disease than whites. Renal disease itself leads to hypertension, which in turn can contribute to progression of renal disease. Although there are numerous mechanisms involved in the process of renal disease progression, the renin-angiotensin system plays a major role as determined by the beneficial response to angiotensin I-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (AT II blockers) of reduced rate of progression in a variety of clinical and experimental renal diseases. Macromolecular trafficking across the glomerulus leading to proteinuria plays a significant role in progression of chronic renal disease. Reversal of this abnormality and reduced stress on capillary walls may be the major mechanisms of beneficial action of ACEIs and AT II blockers in halting renal disease progression. |
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Authors:
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M Martínez-Maldonado |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 16 Suppl 1 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-05-22 Completed Date: 2001-08-23 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 63-6 Citation Subset: IM |
Affiliation:
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Ponce School of Medicine, Ponce, 00732, Puerto Rico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Americans African Continental Ancestry Group Angiotensin II / physiology Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Animals Antihypertensive Agents / therapeutic use* Chronic Disease Disease Progression Humans Hypertension / drug therapy, physiopathology* Kidney Diseases / drug therapy, physiopathology* Kidney Failure, Chronic / physiopathology*, prevention & control Muscle, Smooth, Vascular / physiopathology United States |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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