Document Detail


Role of the humoral factor and postsynaptic sensitization in heterosynaptic facilitation
MedLine Citation:
PMID:  2872600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is shown that heterosynaptic facilitation of the synaptic transmission in the giant neurons of the cerebral ganglion in Planorbis corneus develops due to the diffuse neurohumoral effects on the pre- and postsynaptic structures but not as a result of the local synaptic influences on the presynaptic mechanisms. Using the new biological object it has been confirmed that serotonin from the perfuse solution was a source of the facilitatory action on the n-cholinergic synaptic transmission. It was established that conditioning stimulations facilitated not only the n-cholinergic synaptic transmission but also the ionophoretic acetylcholine potentials. Amplitudes of EPSPs and acetylcholinic potentials increased 4-6 times, while the postsynaptic membrane impedance increased only by 20%. Based on such data it is summarized that sensitization of n-cholinergic receptors of the postsynaptic membrane contributed much to the heterosynaptic facilitation. The possible role of n-cholinergic receptors of the postsynapcit membrane in the processes of the heterosynaptic facilitation and of the conditional training is discussed.
Authors:
V M Storozhuk; I N Antonov
Publication Detail:
Type:  English Abstract; In Vitro; Journal Article    
Journal Detail:
Title:  Neir̆ofiziologiia = Neurophysiology     Volume:  18     ISSN:  0028-2561     ISO Abbreviation:  Neirofiziologiia     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231364     Medline TA:  Neirofiziologiia     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  250-9     Citation Subset:  IM    
Vernacular Title:
Rol' gumoral'nogo faktora i postsinapticheskoĭ sensitizatsii v geterosinapticheskom oblegchenii.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Cholinergic Fibers / drug effects
Ganglia / drug effects,  physiology*
Lysergic Acid Diethylamide / pharmacology
Mollusca
Neurotransmitter Agents / physiology*
Receptors, Nicotinic / physiology
Serotonin / pharmacology
Synapses / physiology*
Synaptic Transmission* / drug effects
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Receptors, Nicotinic; 50-37-3/Lysergic Acid Diethylamide; 50-67-9/Serotonin; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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