Document Detail

Role of the humoral factor and postsynaptic sensitization in heterosynaptic facilitation
MedLine Citation:
PMID:  2872600     Owner:  NLM     Status:  MEDLINE    
It is shown that heterosynaptic facilitation of the synaptic transmission in the giant neurons of the cerebral ganglion in Planorbis corneus develops due to the diffuse neurohumoral effects on the pre- and postsynaptic structures but not as a result of the local synaptic influences on the presynaptic mechanisms. Using the new biological object it has been confirmed that serotonin from the perfuse solution was a source of the facilitatory action on the n-cholinergic synaptic transmission. It was established that conditioning stimulations facilitated not only the n-cholinergic synaptic transmission but also the ionophoretic acetylcholine potentials. Amplitudes of EPSPs and acetylcholinic potentials increased 4-6 times, while the postsynaptic membrane impedance increased only by 20%. Based on such data it is summarized that sensitization of n-cholinergic receptors of the postsynaptic membrane contributed much to the heterosynaptic facilitation. The possible role of n-cholinergic receptors of the postsynapcit membrane in the processes of the heterosynaptic facilitation and of the conditional training is discussed.
V M Storozhuk; I N Antonov
Publication Detail:
Type:  English Abstract; In Vitro; Journal Article    
Journal Detail:
Title:  Neir̆ofiziologiia = Neurophysiology     Volume:  18     ISSN:  0028-2561     ISO Abbreviation:  Neirofiziologiia     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231364     Medline TA:  Neirofiziologiia     Country:  USSR    
Other Details:
Languages:  rus     Pagination:  250-9     Citation Subset:  IM    
Vernacular Title:
Rol' gumoral'nogo faktora i postsinapticheskoĭ sensitizatsii v geterosinapticheskom oblegchenii.
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MeSH Terms
Acetylcholine / pharmacology
Cholinergic Fibers / drug effects
Ganglia / drug effects,  physiology*
Lysergic Acid Diethylamide / pharmacology
Neurotransmitter Agents / physiology*
Receptors, Nicotinic / physiology
Serotonin / pharmacology
Synapses / physiology*
Synaptic Transmission* / drug effects
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Receptors, Nicotinic; 50-37-3/Lysergic Acid Diethylamide; 50-67-9/Serotonin; 51-84-3/Acetylcholine

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