| Role of the humoral factor and postsynaptic sensitization in heterosynaptic facilitation | |
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MedLine Citation:
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PMID: 2872600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is shown that heterosynaptic facilitation of the synaptic transmission in the giant neurons of the cerebral ganglion in Planorbis corneus develops due to the diffuse neurohumoral effects on the pre- and postsynaptic structures but not as a result of the local synaptic influences on the presynaptic mechanisms. Using the new biological object it has been confirmed that serotonin from the perfuse solution was a source of the facilitatory action on the n-cholinergic synaptic transmission. It was established that conditioning stimulations facilitated not only the n-cholinergic synaptic transmission but also the ionophoretic acetylcholine potentials. Amplitudes of EPSPs and acetylcholinic potentials increased 4-6 times, while the postsynaptic membrane impedance increased only by 20%. Based on such data it is summarized that sensitization of n-cholinergic receptors of the postsynaptic membrane contributed much to the heterosynaptic facilitation. The possible role of n-cholinergic receptors of the postsynapcit membrane in the processes of the heterosynaptic facilitation and of the conditional training is discussed. |
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Authors:
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V M Storozhuk; I N Antonov |
Publication Detail:
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Type: English Abstract; In Vitro; Journal Article |
Journal Detail:
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Title: Neir̆ofiziologiia = Neurophysiology Volume: 18 ISSN: 0028-2561 ISO Abbreviation: Neirofiziologiia Publication Date: 1986 |
Date Detail:
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Created Date: 1986-06-30 Completed Date: 1986-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231364 Medline TA: Neirofiziologiia Country: USSR |
Other Details:
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Languages: rus Pagination: 250-9 Citation Subset: IM |
Vernacular Title:
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Rol' gumoral'nogo faktora i postsinapticheskoĭ sensitizatsii v geterosinapticheskom oblegchenii. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Cholinergic Fibers / drug effects Ganglia / drug effects, physiology* Lysergic Acid Diethylamide / pharmacology Mollusca Neurotransmitter Agents / physiology* Receptors, Nicotinic / physiology Serotonin / pharmacology Synapses / physiology* Synaptic Transmission* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 0/Receptors, Nicotinic; 50-37-3/Lysergic Acid Diethylamide; 50-67-9/Serotonin; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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