Document Detail


Role of hsa-miR-325 in the etiopathology of preeclampsia.
MedLine Citation:
PMID:  22710575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preeclampsia (PE) is a common pregnancy-specific syndrome characterized by hypertension and proteinuria. Evidence has demonstrated that hypertensive disorders in pregnancy are associated with alterations in the expression of different microRNAs (miRNAs). miRNAs are endogenously expressed non-coding RNAs that have significant biological and pathological functions due to their potential mechanisms of regulation of gene expression. The purpose of the present study was to investigate the expression of hsa-miR-325 in placental samples of preeclamptic and uncomplicated pregnancy patients. hsa-miR-325 was isolated from placenta tissue samples obtained from 31 preeclamptic and 28 normotensive pregnant females. Quantitative real-time polymerase chain reaction was used to analyze miRNA expression. The expression of hsa-miR‑325 was elevated in uncomplicated pregnancies compared with preeclamptic patients. ΔCt (mean±SD) values were 0.117±0.07 in PE tissues and 0.135±0.051 in normotensive cases (p<0.05). The expression levels correlated with patient blood pressure (p=0.015, r=-0.23), and tended to correlate with body mass index (p=0.065, r=0.261). The expression of hsa-miR-325 was downregulated in the case of PE. Changes in hsa-miR‑325 expression in the case of pregnancy-related hypertensive disorders might affect the oxidative stress pathways and heat-shock protein production. These factors have a strong correlation with the development of PE. We, therefore, suggest that hsa-miR-325 contributes to the pathogenesis of PE.
Authors:
Levente Lázár; Bálint Nagy; Attila Molvarec; András Szarka; János Rigó
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-18
Journal Detail:
Title:  Molecular medicine reports     Volume:  6     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-06     Completed Date:  2012-11-06     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  597-600     Citation Subset:  IM    
Affiliation:
First Department of Obstetrics and Gynecology, Semmelweis University Budapest, H-1085 Budapest, Hungary. lazar_levente@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Pressure
Body Mass Index
Down-Regulation
Female
Heat-Shock Proteins / metabolism
Humans
MicroRNAs / metabolism*
Placenta / metabolism
Pre-Eclampsia / genetics,  metabolism*
Pregnancy
Young Adult
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins; 0/MIRN325 microRNA, human; 0/MicroRNAs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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