Document Detail

Role of homeobox genes in the hypothalamic development and energy balance.
MedLine Citation:
PMID:  23276958     Owner:  NLM     Status:  MEDLINE    
Homeobox genes contribute to the regionalization, patterning and cell differentiation during embryogenesis and organ development. During mammalian embryonic development, homeobox genes, including orthopedia (Otp), a brain-specific homeobox transcription factor (Bsx) and a thyroid transcription factor-1 (TTF-1), are expressed in the hypothalamus. The genetic ablation of these genes indicated that Otp and TTF-1 are essential for the normal morphological development of the hypothalamus, including the arcuate nucleus (ARC), whereas Bsx is not required. In the adult stage, Bsx and TTF-1 continue to be expressed in the hypothalamus, including the ARC, and serve as transcription factors of neuropeptide Y and agouti-related protein. The expression of hypothalamic Bsx and TTF-1 can be altered by the feeding state and appetite regulatory hormones such as ghrelin and leptin. Although Bsx and TTF-1 are essential for normal feeding behavior in adult mice, they exert different effects on the expression of hypothalamic pro-opiomelanocortin (POMC) and body weight homeostasis. Thus, the hypothalamic homeobox genes may contribute to the dissociation of food intake and body weight via AgRP-POMC neurons.
Takao Kaji; Katsunori Nonogaki
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  740-7     Citation Subset:  IM    
Department of Lifestyle Medicine, Translational Research Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
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MeSH Terms
Agouti-Related Protein / genetics,  physiology
Arcuate Nucleus / embryology
DNA-Binding Proteins / genetics*
Eating / physiology
Energy Metabolism / genetics
Genes, Homeobox / physiology*
Ghrelin / physiology
Homeodomain Proteins / biosynthesis,  genetics*
Hypothalamus / embryology*,  physiology*
Leptin / physiology
Nerve Tissue Proteins / biosynthesis,  genetics*
Neuropeptide Y / genetics,  physiology
Nuclear Proteins / genetics,  physiology
Pro-Opiomelanocortin / genetics
Transcription Factors / genetics,  physiology
Reg. No./Substance:
0/Agouti-Related Protein; 0/Agrp protein, mouse; 0/Bsx protein, mouse; 0/DNA-Binding Proteins; 0/Ghrelin; 0/Homeodomain Proteins; 0/Leptin; 0/Nerve Tissue Proteins; 0/Neuropeptide Y; 0/Nuclear Proteins; 0/Otp protein, mouse; 0/Transcription Factors; 0/Ttf1 protein, mouse; 0/thyroid nuclear factor 1; 66796-54-1/Pro-Opiomelanocortin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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