| Role of histamine in the regulation of coronary circulation. | |
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MedLine Citation:
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PMID: 9085353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the role of endogenous histamine in the regulation of reactive hyperaemia (RH) and coronary autoregulation in isolated rat hearts. The basal release of cardiac histamine (perfusion pressure 60 cm H2O) amounted to 100-200 pmol/min/g wt. During the first 15 s following 30 s of coronary occlusion, the release of histamine increased about three times and returned to basal levels after approximately 90 s, paralleling the changes of coronary flow (CF). Blockade of H1-receptors increased basal CF by 23 +/- 2%, significantly reduced blood flow debt and prolonged the duration of RH. Blockade of H2- and H3-receptors produced a significant decline of CF, decreased RH flow and diminished RH by 40 +/- 3%. Blockade of all three classes of histamine receptors indicated that endogenous histamine exerts predominantly vasodilatory effects (mediated by H2- and H3-receptors) on coronary circulation. Histamine-induced vasodilation appears to be NO-dependent. Changes of coronary perfusion pressure from 20 to 120 cm H2O were accompanied by an almost linear decrease of histamine release from about 200 to 45-50 pmol/min/g wt. Blockade of histamine receptors decreased, while L-NAME significantly widened the autoregulatory range of the isolated rat heart, reduced CF and release of NO, but reversed the pattern of histamine release leaving the autoregulatory range unaltered, which indicate that endogenous histamine does not play a role in the regulation of coronary autoregulation. |
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Authors:
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M M Kostić; V L Jakovljević |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 45 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 1996 |
Date Detail:
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Created Date: 1997-06-06 Completed Date: 1997-06-06 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECH REPUBLIC |
Other Details:
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Languages: eng Pagination: 297-303 Citation Subset: IM |
Affiliation:
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Institute of Physiology, Faculty of Medicine, University of Kragujevac, Yugoslavia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects, physiology* Enzyme Inhibitors / pharmacology Histamine / physiology* Homeostasis / drug effects, physiology Hyperemia / physiopathology Myocardium / chemistry NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / physiology Perfusion Rats Rats, Wistar Receptors, Histamine / physiology Theophylline / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Receptors, Histamine; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-45-6/Histamine; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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