Document Detail

Role of histamine in the pathophysiology of asthma: immunomodulatory and anti-inflammatory activities of H1-receptor antagonists.
MedLine Citation:
PMID:  12517576     Owner:  NLM     Status:  MEDLINE    
Cumulative clinical and laboratory evidence on histamine and its actions suggests that it has a pathophysiologic role in asthma. These findings have renewed interest in the potential therapeutic role of H1 antihistamines in this disease. A murine model of allergen-induced airway inflammation and methacholine-induced airway hyperresponsiveness has been used to clarify mechanisms of airway function, to identify potential therapeutic targets, and to investigate the effects of the H1-receptor antagonist fexofenadine. Findings suggest that there may be a role for second-generation antihistamines in treating asthma, with patient selection as well as dosing both important therapeutic considerations. Because high-dose therapy may be required to achieve a clinical response, agents with the widest therapeutic window and the lowest potential for sedation would offer the greatest therapeutic potential.
Erwin W Gelfand
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  113 Suppl 9A     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-08     Completed Date:  2003-01-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2S-7S     Citation Subset:  AIM; IM    
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
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MeSH Terms
Adjuvants, Immunologic / pharmacology,  therapeutic use*
Anti-Inflammatory Agents / immunology*,  pharmacology,  therapeutic use*
Asthma / immunology*,  physiopathology*
Histamine / immunology*,  physiology*
Histamine H1 Antagonists / immunology*,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Anti-Inflammatory Agents; 0/Histamine H1 Antagonists; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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