Document Detail

Role of histamine H1- and H2-receptors in postprandial intestinal hyperemia.
MedLine Citation:
PMID:  7124953     Owner:  NLM     Status:  MEDLINE    
Studies were conducted in anesthetized dogs to assess whether histamine H1- and/or H2-receptors play a role in post-prandial intestinal hyperemia. The vascular and metabolic responses of jejunal segments to intra-arterial infusion of histamine and luminal placement of food before and after administration of tripelennamine, an H1-receptor antagonist, metiamide, an H2-receptor antagonist, and the combination of both antagonists were compared. Administration of the antagonists had no effect of jejunal blood flow and intestinal oxygen uptake (VO2). Tripelennamine or metiamide alone attenuated while the combination of both blocked the histamine-induced increases in blood flow and VO2. Metamide alone had no effect on the food-induced increases in flow and VO2. Tripelennamine significantly attenuated the food-induced increase in flow and blocked the increase in VO2. A 30% increase in flow was reduced to 15% after tripelennamine. The effects of tripelennamine plus metiamide were statistically the same as those of tripelennamine alone. It is concluded that endogenous histamines may play a role in postprandial intestinal hyperemia, and the effect is primarily mediated by the H1-receptors.
C C Chou; H Siregar
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  243     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G248-52     Citation Subset:  IM    
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MeSH Terms
Histamine / pharmacology
Jejunum / blood supply*,  drug effects,  physiology
Metiamide / pharmacology
Oxygen Consumption / drug effects
Receptors, Histamine / physiology*
Receptors, Histamine H1 / physiology*
Receptors, Histamine H2 / physiology*
Regional Blood Flow / drug effects
Tripelennamine / pharmacology
Grant Support
Reg. No./Substance:
0/Receptors, Histamine; 0/Receptors, Histamine H1; 0/Receptors, Histamine H2; 34839-70-8/Metiamide; 51-45-6/Histamine; 91-81-6/Tripelennamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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