Document Detail


Role of the hepatic xanthine oxidase in thyroid dysfunction: effect of thyroid hormones in oxidative stress in rat liver.
MedLine Citation:
PMID:  9875437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of thyroid hormones on the hepatic xanthine oxidase activity was studied in rats after the intraperitoneal injections of comthyroid (triiodotyronine:thyroxine = 1:4) at 0.3 mg/kg for 3 consecutive days. The aim of this study was to understand the precise mechanism of hyperthyroidism induced by oxidative stress. The concentration of lipid peroxides determined indirectly by the measurement of thiobarbituric acid reactants was increased in comthyroid treated rats. The hepatic glutathione content was decreased in comthyroid injected rat compared to the euthyroid state. It was also observed that the increment of xanthine oxidase activity has a profound role in oxygen radicals generation system in comthyroid treated rat. These findings suggest that the enhanced xanthine oxidase activity and depleting glutathione content in comthyroid treated rats result in pathophysiological oxidative stress including an increment of hepatic lipid peroxidation.
Authors:
K Huh; T H Kwon; J S Kim; J M Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of pharmacal research     Volume:  21     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1999-02-09     Completed Date:  1999-02-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  KOREA    
Other Details:
Languages:  eng     Pagination:  236-40     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Pharmacy, Yeungnam University, Gyongsan, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature / drug effects
Free Radicals / metabolism
Glutathione / metabolism
Lipid Peroxidation / drug effects
Liver / drug effects,  enzymology*,  metabolism
Male
Oxidative Stress / drug effects*
Proteins / metabolism
Rats
Rats, Sprague-Dawley
Thyroid Diseases / enzymology*
Thyroid Hormones / pharmacology*
Xanthine Dehydrogenase / metabolism
Xanthine Oxidase / physiology*
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Proteins; 0/Thyroid Hormones; 70-18-8/Glutathione; EC 1.17.1.4/Xanthine Dehydrogenase; EC 1.17.3.2/Xanthine Oxidase

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